Independent effects of age and nucleus basalis magnocellularis lesion: maze learning, cortical neurochemistry, and morphometry.
Independent effects of age and nucleus basalis magnocellularis lesion: maze learning, cortical neurochemistry, and morphometry.
复制标题
年龄和大细胞基底核病变的独立影响：迷宫学习、皮质神经化学和形态测量。
DOI：
10.1037//0735-7044.106.5.776
复制
发表时间：
1992
影响因子：
1.9
通讯作者：
Masliah,E
中科院分区：
文献类型：
--
作者：
Connor,DJ;Thal,LJ;Mandel,RJ;Langlais,PJ;Masliah,E
Assessed the effects of age and lesion of the cholinergic nucleus basalis magnocellularis (NBm) behaviorally, morphologically, and biochemically. Groups consisted of rats lesioned 1 mo before testing, rats lesioned 13 mo before testing, and their respective age-matched controls. Both age and lesion independently induced behavioral deficits in performance on 2 water maze tasks. The combined effect of these 2 factors produced behavioral deficits equal to the sum of the individual impairments. NBm lesion produced a 28% decrease in anterior cortical choline acetyltransferase activity and a 20% decrease in synaptophysin immunoreactivity in the neocortex that was stable over a 12-mo period. Neither neuritic plaque nor neurofibrillary-tanglelike structures were found in the brains of 18-mo-old control rats, nor were they found in NBm-lesioned rats examined 15 mo postlesion. There was an age-related decrease in homovanillic acid levels in both control and NBm groups, which suggests a decrease in dopamine turnover. These results show a lack of biochemical and behavioral recovery after NBm lesion and suggest that the effects of age on behavior are independent of NBm-cortical dysfunction.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
