Early manifestations of manganese neurotoxicity in humans: An update
Early manifestations of manganese neurotoxicity in humans: An update
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DOI：
10.1006/enrs.1997.3710
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发表时间：
1997-01-01
影响因子：
8.3
通讯作者：
Baldwin, M
中科院分区：
文献类型：
--
作者：
Mergler, D;Baldwin, M
可以检测到与职业和环境暴露于锰相关的神经毒性功能障碍的早期迹象;在没有临床表现的情况下，可以使用神经生理学和神经行为学测试。虽然个别研究的结果各不相同，但它们共同显示了运动功能减慢，震颤增加，反应速度降低，嗅觉增强，可能的记忆和智力缺陷以及情绪变化的模式。这一总体描述与锰对中枢神经系统的作用一致。在迄今为止的报告中，锰暴露的内部参数（血锰、尿锰、发锰）与外部测量和神经纤维结局之间的剂量-效应关系几乎没有一致性。一些研究表明存在剂量-效应关系，但需要进一步澄清。(C)北京：科学出版社.
It is possible to detect early signs of neurotoxic dysfunction associated with occupational and environmental exposure to manganese; neurophysiologic and neurobehavioral tests can be used in the absence of clinical manifestations. Although outcomes from individual studies vary, they collectively show a pattern of slowing motor functions, increased tremor, reduced response speed, enhanced olfactory sense, possible memory and intellectual deficits, and mood changes. This overall portrait is consistent with the action of manganese on the central nervous system. In reports to date, there is little consistency in dose-effect relationships between internal parameters of manganese exposure (blood manganese, urinary manganese, hair manganese) and external measures and neurolose outcomes. Several studies suggest the existence of dose-effect relationships, but additional clarification is needed. (C) 1997 Academic Press.