The contribution of NMDA receptors in the dorsolateral striatum to egocentric response learning.
The contribution of NMDA receptors in the dorsolateral striatum to egocentric response learning.
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DOI：
10.1037/0735-7044.119.4.953
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发表时间：
2005-08
影响因子：
1.9
通讯作者：
C. A. Palencia;M. Ragozzino
中科院分区：
文献类型：
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作者：
C. A. Palencia;M. Ragozzino
本研究检查了注射到背外侧纹状体的 N-甲基-D-天冬氨酸 (NMDA) 竞争性拮抗剂 2-氨基-5-膦基戊酸 (AP-5) 对反应辨别的获得和逆转学习的影响。雄性 Long-Evans 大鼠在改良的十字迷宫中连续两天进行测试。测试前 5 分钟输注盐水或 AP-5（5 或 25 nM）。在习得过程中，老鼠学会了向左或向右转。在反向学习中，老鼠学会了向相反的方向转向。 25 nmol（而非 5 nmol）的 AP-5 输注会损害反应获取。 AP-5 剂量均不会损害反应逆转学习。结果表明，背外侧纹状体中的 NMDA 受体对于自我中心反应辨别的初始学习至关重要。
The present study examined the effects of the N-methyl-D-aspartate (NMDA) competitive antagonist, 2-amino-5-phosphonopentanoic acid (AP-5), injected into the dorsolateral striatum on the acquisition and reversal learning of a response discrimination. Male Long-Evans rats were tested across 2 consecutive days in a modified cross-maze. An infusion of either saline or AP-5 (5 or 25 nM) occurred 5 min prior to testing. In acquisition rats learned to turn left or right. In reversal learning rats learned to turn in the opposite direction. An AP-5 infusion at 25 nmol, but not 5 nmol, impaired response acquisition. Neither AP-5 dose impaired response reversal learning. The results suggest that NMDA receptors in the dorsolateral striatum are critical for the initial learning of an egocentric response discrimination.