Cost-Effective Fiber Optic Solutions for Biosensing.
Cost-Effective Fiber Optic Solutions for Biosensing.
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DOI：
10.3390/bios12080575
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发表时间：
2022-07-28
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影响因子：
--
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--
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在过去的几年里，光纤传感器已经被证明是一种可靠的、多功能的生物传感工具。光纤生物传感器(OFBs)是一种使用光纤作为传感器的分析设备，具有易于涂覆和生物功能化的优点，允许实时监测所有功能化和检测，而且体积小，几何上灵活，从而允许设备小型化和便携，用于护理点(POC)测试。了解到这种生物传感工具的潜力，本文综述了目前报道的最具成本效益的OFBs。重点介绍了不同的光纤配置，即端面反射光纤、非包层光纤、D形和U形光纤、尖端光纤、球谐振器光纤、锥形光纤、光扩散光纤和特种光纤。提出并讨论了增强OFBs在医学领域的应用的封装技术，即在皮下、经皮、内窥镜手术以及可穿戴结构中的应用。使用智能手机硬件对OFBs进行讯问的方法是获得成本效益高的传感方法的好方法。本文介绍了这类询问方法的不同体系结构及其各自的应用。最后介绍了OFBs在监测人类生活和福祉三个重要领域中的应用：癌症生物标志物的检测、心血管生物标志物的检测和环境监测。
In the last years, optical fiber sensors have proven to be a reliable and versatile biosensing tool. Optical fiber biosensors (OFBs) are analytical devices that use optical fibers as transducers, with the advantages of being easily coated and biofunctionalized, allowing the monitorization of all functionalization and detection in real-time, as well as being small in size and geometrically flexible, thus allowing device miniaturization and portability for point-of-care (POC) testing. Knowing the potential of such biosensing tools, this paper reviews the reported OFBs which are, at the moment, the most cost-effective. Different fiber configurations are highlighted, namely, end-face reflected, unclad, D- and U-shaped, tips, ball resonators, tapered, light-diffusing, and specialty fibers. Packaging techniques to enhance OFBs’ application in the medical field, namely for implementing in subcutaneous, percutaneous, and endoscopic operations as well as in wearable structures, are presented and discussed. Interrogation approaches of OFBs using smartphones’ hardware are a great way to obtain cost-effective sensing approaches. In this review paper, different architectures of such interrogation methods and their respective applications are presented. Finally, the application of OFBs in monitoring three crucial fields of human life and wellbeing are reported: detection of cancer biomarkers, detection of cardiovascular biomarkers, and environmental monitoring.
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影响因子：
3.7
作者：
Martinez P;Hernández-Losa J;Montero MÁ;Cedrés S;Castellví J;Martinez-Marti A;Tallada N;Murtra-Garrell N;Navarro-Mendivill A;Rodriguez-Freixinos V;Canela M;Ramon y Cajal S;Felip E
通讯作者：
Felip E
DOI：
10.1038/lsa.2016.36
发表时间：
2016-02
期刊：
Light, science & applications
影响因子：
--
作者：
Allsop T;Arif R;Neal R;Kalli K;Kundrát V;Rozhin A;Culverhouse P;Webb DJ
通讯作者：
Webb DJ
影响因子：
5
作者：
Boeddinghaus, Jasper;Reichlin, Tobias;Mueller, Christian
通讯作者：
Mueller, Christian
影响因子：
5.6
作者：
Aitkulov, A.;Sypabekova, M.;Tosi, D.
通讯作者：
Tosi, D.
影响因子：
2.7
作者：
Cennamo, Nunzio;Zeni, Luigi;Minardo, Aldo
通讯作者：
Minardo, Aldo