FGF23 is elevated in Gambian children with rickets
FGF23 is elevated in Gambian children with rickets
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DOI：
10.1016/j.bone.2007.11.014
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发表时间：
2008-04-01
期刊：
影响因子：
4.1
通讯作者：
Pettifor, John M.
中科院分区：
文献类型：
--
作者：
Prentice, Ann;Ceesay, Mustapha;Pettifor, John M.
目的：成纤维细胞生长因子23（FGF 23）是一种磷酸尿因子，其在与低磷酸盐血症和佝偻病相关的几种疾病中升高。在缺乏维生素D的情况下，佝偻病已在非洲和亚洲人群中报告，钙摄入量低，但风险因素的定义已被证明是难以捉摸的。本研究的目的是描述一系列冈比亚儿童的生化特征并测量FGF 23，这些儿童患有病因不明的佝偻病，血浆25-羟基维生素D（250 HD）高于维生素D缺乏性佝偻病的典型范围。46名患者（30名男性，16名女性）患有佝偻病的典型骨畸形，年龄为1.1-16.4岁（几何平均值，3.4岁）。活动性佝偻病（X线片和/或血浆碱性磷酸酶升高）存在于28%。所有患者的血浆25-羟基维生素D均高于20 nmol/l。结果：佝偻病患儿血浆磷酸盐、25-羟维生素D、1，25-二羟维生素D和总碱性磷酸酶水平均低于当地儿童。活动性佝偻病患者的甲状旁腺激素浓度升高。患者的FGF 23浓度显著高于当地儿童（几何平均值（-1SID，+1SD，范围）RU/ml：367（87，1552，46-7052，n = 39）vs 51（23，112，3-130，n = 30），p
Objectives: Fibroblast growth factor 23 (FGF23) is a phosphaturic factor that is elevated in several diseases associated with hypophosphatemia and rickets. Rickets in the absence of vitamin D deficiency has been reported in African and Asian populations with a low calcium intake but the definition of risk factors has proved elusive. The aim of the study was to characterize the biochemical profile and measure FGF23 in a series of Gambian children who had presented with rickets of unknown etiology and a plasma 25-hydroxyvitamin D (250HD) above the range typical of vitamin D-deficiency rickets.Methods: The 46 patients (30 males, 16 females) had bone deformities typical of rickets and were 1.1-16.4 years old (geometric mean, 3.4 years). Active rickets (on radiographs and/or elevated plasma alkaline phosphatase) was present in 28%. Plasma 25-hydroxyvitamin D was above 20 nmol/l in all patients. Concentrations of plasma FGF23, phosphate and other relevant biochemical analytes were measured in stored samples of fasting, early morning plasma and compared with those measured in samples collected from local children and stored under similar conditions.Results: The rickets patients had lower plasma phosphate, lower 25-hydroxyvitamin D, higher 1,25-dihydroxyvitamin D and elevated total alkaline phosphatase than local children. Those with active rickets had raised parathyroid hormone concentration. The patients had significantly higher FGF23 concentration than local children (geometric mean (-1SID, + 1SD, range) RU/ml: 367 (87, 1552, 46-7052, n = 39) vs 51 (23, 112, 3-130, n = 30), p