Long-term outcome of panic disorder after short-term imipramine and behavioral group treatment: 2.9-year naturalistic follow-up study.
Long-term outcome of panic disorder after short-term imipramine and behavioral group treatment: 2.9-year naturalistic follow-up study.
复制标题
短期丙咪嗪和行为团体治疗后恐慌症的长期结果：2.9 年自然随访研究。
DOI：
10.1097/00004714-199302000-00003
复制
发表时间：
1993
影响因子：
2.9
通讯作者：
S. Woods
中科院分区：
文献类型：
--
作者：
L. Nagy;J. Krystal;D. Charney;K. Merikangas;S. Woods
28例DSM-III诊断为广场恐怖症伴惊恐发作的患者，完成了4个月的药物和行为联合治疗计划，然后出院服用丙咪嗪，出院后1至5年接受了采访。在随访时，一半的患者没有药物治疗，8名患者接受了较低剂量的丙咪嗪，2名患者接受了与出院时相同的剂量，4名患者接受了其他抗恐慌药物。在随访时，惊恐发作频率仍然降低，所有焦虑和所有损害评级也是如此。这些改善是相似的患者之间接受和不接受丙咪嗪在这个时候。长期结果与随访期间的非药物治疗和入院时抑郁症的终身诊断无关。我们的数据表明，改善后观察到的治疗与丙咪嗪和行为疗法4个月后保持1至5年，即使对于许多患者谁减少剂量或中断丙咪嗪。需要长期随机研究来比较治疗的疗效并确定治疗持续时间。
Twenty-eight patients with a DSM-III diagnosis of agoraphobia with panic attacks who completed a 4-month combined drug and behavioral treatment program and who were then discharged on imipramine were interviewed 1 to 5 years after being discharged. At the time of follow-up, half of the patients were medication free, eight were receiving a lower dose of imipramine, two were receiving the same dose as at the time of discharge, and four patients were receiving other antipanic medications. Panic attack frequency remained reduced at the time of follow-up, as did all anxiety and all impairment ratings. These improvements were similar between patients receiving and not receiving imipramine at this time. Long-term outcome was independent of nonpharmacological therapy during the follow-up interval and lifetime diagnosis of major depression at the time of admission. Our data suggest that improvement observed after 4 months of treatment with imipramine and behavioral therapy is maintained after 1 to 5 years, even for many patients who reduced the dose of or discontinued imipramine. Long-term, randomized studies are needed to compare the efficacy of treatments and to determine treatment duration.