Site-specific integration of adeno-associated virus into an episome with the target locus via a deletion-substitution mechanism.

Site-specific integration of adeno-associated virus into an episome with the target locus via a deletion-substitution mechanism.
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通过删除取代机制将腺相关病毒定点整合到具有目标位点的附加体中。

DOI:
10.1128/jvi.72.7.6195-6198.1998
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发表时间:
1998
影响因子:
5.4
通讯作者:
Berns,KI
Berns,KI
中科院分区:
医学2区
文献类型:
--
作者:
Dyall,J;Berns,KI

文献摘要

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五个位点特异性腺相关病毒整合体中产生的模型系统与EB病毒为基础的穿梭载体的特点。结果表明,重组的缺失取代机制。
Five site-specific adeno-associated virus integrants generated in a model system with an Epstein-Barr virus- based shuttle vector have been characterized. The results suggest a deletion-substitution mechanism of recombination.