Ionization detail parameters and cluster dose: a mathematical model for selection of nanodosimetric quantities for use in treatment planning in charged particle radiotherapy.
Ionization detail parameters and cluster dose: a mathematical model for selection of nanodosimetric quantities for use in treatment planning in charged particle radiotherapy.
复制标题
电离细节参数和簇剂量：用于选择纳米剂量量的数学模型，用于带电粒子放射治疗的治疗计划。
DOI：
10.1088/1361-6560/acea16
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发表时间：
2023
影响因子：
3.5
通讯作者：
Schulte,Reinhard
中科院分区：
文献类型：
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作者：
Faddegon,Bruce;Blakely,EleanorA;Burigo,Lucas;Censor,Yair;Dokic,Ivana;DomínguezKondo,Naoki;Ortiz,Ramon;RamosMéndez,José;Rucinski,Antoni;Schubert,Keith;Wahl,Niklas;Schulte,Reinhard
目的提出一种将电离细节（ID）（电离沿着粒子轨迹的详细空间分布）应用于质子和离子束放射治疗计划（RTP）的数学模型。方法我们的模型提供了选择RTP的首选ID参数（IP），该参数与生物效应最相关。团簇剂量的建议，以弥合纳米级的IP和宏观RTP之间的巨大差距。使用公开的质子通过氩气的细胞存活测量来证明Ip的选择，比较十九个Ip：N k，k= 2，3，.，10表示每个粒子k个或更多个的簇中的电离数，并且F k，k= 1，2，.，10，每个粒子k个或更多的簇的数目。然后我们描述了该模型在基于ID的RTP中的应用，并提出了临床转化的途径。主要结果对于需氧细胞，首选的IP是N4和F5，对于缺氧细胞，首选的IP是N5和F7。发现具有相同的LET或优选的N k的梁的细胞存活率的显着差异。相反，无论离子束原子序数或能量如何，有氧细胞的F5和缺氧细胞的F7均无显著差异。此外，这些IP用相同的簇剂量照射的细胞具有相同的细胞存活。基于这些初步结果和其他令人信服的结果在纳米剂量测定，这是合理的断言，IP存在更密切相关的生物效应比目前的LET为基础的方法和微剂量RBE为基础的模型中使用的粒子RTP。然而，更多的生物学变量，如细胞系和周期阶段，以及离子束脉冲结构和速率仍然需要调查.SignificanceOur模型提供了一个实用的手段来选择首选IP从放射生物学数据，并将IP的粒子RTP的宏观集群剂量。
ObjectiveTo propose a mathematical model for applying ionization detail (ID), the detailed spatial distribution of ionization along a particle track, to proton and ion beam radiotherapy treatment planning (RTP).ApproachOur model provides for selection of preferred ID parameters (I p) for RTP, that associate closest to biological effects. Cluster dose is proposed to bridge the large gap between nanoscopic I p and macroscopic RTP. Selection of I p is demonstrated using published cell survival measurements for protons through argon, comparing results for nineteen I p: N k, k= 2, 3,..., 10, the number of ionizations in clusters of k or more per particle, and F k, k= 1, 2,..., 10, the number of clusters of k or more per particle. We then describe application of the model to ID-based RTP and propose a path to clinical translation.Main resultsThe preferred I p were N 4 and F 5 for aerobic cells, N 5 and F 7 for hypoxic cells. Significant differences were found in cell survival for beams having the same LET or the preferred N k. Conversely, there was no significant difference for F 5 for aerobic cells and F 7 for hypoxic cells, regardless of ion beam atomic number or energy. Further, cells irradiated with the same cluster dose for these I p had the same cell survival. Based on these preliminary results and other compelling results in nanodosimetry, it is reasonable to assert that I p exist that are more closely associated with biological effects than current LET-based approaches and microdosimetric RBE-based models used in particle RTP. However, more biological variables such as cell line and cycle phase, as well as ion beam pulse structure and rate still need investigation.SignificanceOur model provides a practical means to select preferred I p from radiobiological data, and to convert I p to the macroscopic cluster dose for particle RTP.