BDNF Val66Met polymorphism and goal-directed behavior in healthy elderly - evidence from auditory distraction
BDNF Val66Met polymorphism and goal-directed behavior in healthy elderly - evidence from auditory distraction
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DOI：
10.1016/j.neuroimage.2012.08.079
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发表时间：
2013-01-01
期刊：
影响因子：
5.7
通讯作者：
Beste, Christian
中科院分区：
文献类型：
--
作者：
Getzmann, Stephan;Gajewski, Patrick D.;Beste, Christian
衰老影响了人们将注意力集中在特定任务上的能力，以及忽略干扰因素的能力。这些功能有助于响应控制过程，额纹状体网络已被证明发挥重要作用。在这些网络中，脑源性神经营养因子（BDNF），这是已知的老化效应的基础，发挥着关键作用。我们调查了122名健康老年人的事件相关电位（ERPs）的功能性BDNF Val 66 Met多态性如何影响认知子过程，构成一个周期的分心，定向和重新集中注意力。使用听觉分心范例，我们发现，瓦尔/瓦尔基因型赋予其运营商的不利条件。这一劣势部分被强化的注意力转移机制所弥补。这可能是基于反应选择过程更容易受到干扰干扰，在这个基因型组。反映瞬时感觉记忆过程的过程，或注意力的重新定位没有受到BDNF Val 66 Met多态性的影响，这表明BDNF对反应控制相关机制的重要性高于刺激处理。这些结果补充了最近的文献，表明Met等位基因为其携带者带来了一些好处。我们建议一个帐户统一的不同结果的BDNF Val 66 Met协会的研究执行功能，根据BDNF在额纹状体电路的作用。(C)2012 Elsevier Inc. All rights reserved.
Aging affects the ability to focus attention on a given task and to ignore distractors. These functions subserve response control processes for which fronto-striatal networks have been shown to play an important role. Within these networks, the brain-derived-neurotrophic-factor (BDNF), which is known to underlie aging effects, plays a pivotal role. We investigated how cognitive subprocesses constituting a cycle of distraction, orientation and refocusing of attention are affected by the functional BDNF Val66Met polymorphism using event-related potentials (ERPs) in 122 healthy elderly. Using an auditory distraction paradigm we found that the Val/Val genotype confers a disadvantage to its carriers. This disadvantage was partly compensated by intensified attentional shifting mechanisms. It could be based on response selection processes being more vulnerable against interference from distractors in this genotype group. Processes reflecting transient sensory memory processes, or the re-orientation of attention were not affected by the BDNF Val66Met polymorphism, suggesting a higher importance of BDNF for mechanisms related to response control, than stimulus processing. The results add on recent literature showing that the Met allele confers some benefit to its carriers. We suggest an account for unifying different results of BDNF Val66Met association studies in executive functions, based on the role of BDNF in fronto-striatal circuits. (C) 2012 Elsevier Inc. All rights reserved.