Platelets Kill Intraerythrocytic Malarial Parasites and Mediate Survival to Infection
Platelets Kill Intraerythrocytic Malarial Parasites and Mediate Survival to Infection
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DOI：
10.1126/science.1166296
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发表时间：
2009-02-06
期刊：
影响因子：
56.9
通讯作者：
Foote, Simon J.
中科院分区：
文献类型：
--
作者：
McMorran, Brendan J.;Marshall, Vikki M.;Foote, Simon J.
血小板通过促进受感染的红细胞在脑血管系统内的隔离而在疟疾感染的发病机制中起关键作用。但是血小板在抵抗微生物感染的先天保护中也有很好的作用。我们发现，纯化的人血小板杀死了在红细胞中培养的恶性疟原虫寄生虫。阿司匹林和其他血小板抑制剂对血小板功能的抑制可消除人血小板对恶性疟原虫的致死作用。同样，血小板缺乏和阿司匹林治疗的小鼠在红细胞感染夏氏疟原虫期间更容易死亡。老鼠和人类的血小板都能与感染疟疾的红细胞结合并杀死其中的寄生虫.这些结果表明，血小板在红细胞感染的早期阶段的保护功能，不同于他们在脑型疟疾的作用。
Platelets play a critical role in the pathogenesis of malarial infections by encouraging the sequestration of infected red blood cells within the cerebral vasculature. But platelets also have well- established roles in innate protection against microbial infections. We found that purified human platelets killed Plasmodium falciparum parasites cultured in red blood cells. Inhibition of platelet function by aspirin and other platelet inhibitors abrogated the lethal effect human platelets exert on P. falciparum parasites. Likewise, platelet- deficient and aspirin- treated mice were more susceptible to death during erythrocytic infection with Plasmodium chabaudi. Both mouse and human platelets bind malarial- infected red cells and kill the parasite within. These results indicate a protective function for platelets in the early stages of erythrocytic infection distinct from their role in cerebral malaria.