Multiscale Genome Organization: Dazzling Subject and Inventive Methods.
Multiscale Genome Organization: Dazzling Subject and Inventive Methods.
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多尺度基因组组织：令人眼花缭乱的主题和发明方法。
DOI：
10.1016/j.bpj.2020.04.007
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发表时间：
2020
影响因子：
3.4
通讯作者：
Schlick,Tamar
中科院分区：
文献类型：
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作者：
Schlick,Tamar
当我为我们的特刊《染色质的多尺度建模》撰写这篇社论时，我们被一个与冠状病毒大流行有关的关注和社交距离的世界所包围。一年前，我们在莱舒什举行的BPS主题会议上，在法国阿尔卑斯山享受了一次国际聚会和令人惊叹的风景，这似乎是一个无忧无虑的世界。1和2），这启发了这一系列的文章。这次会议是由托马斯·毕晓普、拉尔斯·诺登斯科尔德、安杰伊·斯塔夏克和我共同组织的。正如我在《BPS公报》的会议摘要中所写的那样：在勃朗峰的背景下，提醒与会者会议的崇高目标，会议汇集了70位生物学家，化学家，物理学家和数学家，通过新的概念方法和观点，讨论和发起合作，推进染色质结构，动力学，功能和应用领域。值得注意的是，会议将实验学家与理论家和建模者无缝地融合在一起，强调了技术和思想之间的相互作用。[The]这些主题强调了染色质复杂的多尺度特征和性质，从DNA到核组织和相互作用，激励科学家讨论在许多空间和时间尺度上开发模型和实验策略，以解决染色质折叠问题的所有相关组成部分和基因表达的表观基因组调控。这种多尺度的方法，结合实验数据和建模和信息学，是必要的提取和识别各种尺度上的结构和功能关系，从单个碱基对到整个基因组，并追求在医学和基因组学的重要应用。虽然我们享受温暖阳光明媚的春天天气的头几天，第三天带来了
As I write this editorial for our special issue, Multiscale Modeling of Chromatin, we are surrounded in a world of concern and social distancing related to the coronavirus pandemic. I recall, as if in a dream, the seemingly carefree world of just one year ago, when we enjoyed an international gathering and breathtaking scenery in the French Alps during our wonderful BPS Thematic Meeting in Les Houches (see group photos in Figs. 1 and 2), which inspired this collection of articles. The meeting was coorganized by Thomas Bishop, Lars Nordenskiold, Andrzej Stasiak, and I. As I wrote in a summary of that meeting for the BPS Bulletin:With Mont Blanc in the background reminding participants of the lofty meeting goals, the meeting brought together 70 biologists, chemists, physicists, and mathematicians to discuss and launch collaborations and advance the field of chromatin structure, dynamics, function, and applications through new conceptual approaches and perspectives. Notably, the meeting merged experimentalists with theoreticians and modelers in the program seamlessly, emphasizing the interplay between techniques and ideas...[The] themes underscored the complex multiscale features and properties of chromatin, from DNA to nuclear organization and interactions, inspiring scientists to discuss the development of models and experimental strategies on many spatial and temporal scales needed to address all relevant components of the chromatin folding problem and the epigenomic regulation of gene expression. Such multiscale approaches, combining experimental data and modeling and informatics, are necessary to extract and identify structure and function relationships on various scales, from individual base pairs to whole genomes, and to pursue important applications in medicine and genomics.... While we enjoyed warm sunny spring weather for the first couple days, the third day brought