Diabetes Mellitus in Elkhounds Is Associated with Diestrus and Pregnancy
Diabetes Mellitus in Elkhounds Is Associated with Diestrus and Pregnancy
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DOI：
10.1111/j.1939-1676.2010.0630.x
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发表时间：
2010-11-01
影响因子：
2.6
通讯作者：
Kampe, O.
中科院分区：
文献类型：
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作者：
Fall, T.;Hedhammar, A.;Kampe, O.
背景：雌性猎犬患糖尿病的风险增加，妊娠期糖尿病的发生也有报道。研究背景：雌性猎犬的糖尿病发病与动情周期有关。动物：63只患有糖尿病的猎犬和26只健康对照。方法：复习63只患有糖尿病的猎犬的医疗记录，并联系其主人以获得随访信息。26只狗从确诊当天的血液样本中获得。对26只健康犬进行了葡萄糖、果糖胺、C肽、生长激素(GH)、胰岛素样生长因子-1、孕酮和谷氨酸脱羧酶亚型65-自身抗体的检测和比较。采用Logistic模型分析临床变量与卵巢子宫切除术后发生糖尿病和永久性糖尿病的关系。结果：所有受试者均为正常雌性，确诊时有7只(11%)已怀孕。糖尿病的首次临床症状出现在发情后30天(IQR)的中位数(IQR，3-45)，诊断是在发情后46天(IQR，27-62)。与发情后时间相匹配的对照组相比，糖尿病患者的生长激素浓度较高，孕酮浓度较低。在接受OHE治疗的狗中，46%的狗在确诊时血糖浓度较高(优势比[OR]，1.2；P=0.03)且从诊断到手术的时间(OR，1.5；P=0.05)较长(OR，1.5；P=0.05)时，糖尿病缓解的几率较低。即刻OHE可改善糖尿病缓解期预后。
Background: Female Elkhounds are shown to be at increased risk for diabetes mellitus, and occurrence of diabetes during pregnancy has been described in several cases.Hypothesis: Onset of diabetes mellitus in Elkhounds is associated with diestrus.Animals: Sixty-three Elkhounds with diabetes mellitus and 26 healthy controls.Methods: Medical records from 63 Elkhounds with diabetes were reviewed and owners were contacted for follow-up information. Blood samples from the day of diagnosis were available for 26 dogs. Glucose, fructosamine, C-peptide, growth hormone (GH), insulin-like growth factor-1, progesterone, and glutamate decarboxylase isoform 65-autoantibodies were analyzed and compared with 26 healthy dogs. Logistic models were used to evaluate the association of clinical variables with the probability of diabetes and with permanent diabetes mellitus after ovariohysterectomy (OHE).Results: All dogs in the study were intact females and 7 dogs (11%) were pregnant at diagnosis. The 1st clinical signs of diabetes mellitus occurred at a median of 30 days (interquartile range [IQR], 3-45) after estrus, and diagnosis was made at a median of 46 days (IQR, 27-62) after estrus. Diabetes was associated with higher concentrations of GH and lower concentrations of progesterone compared with controls matched for time after estrus. Forty-six percent of dogs that underwent OHE recovered from diabetes with a lower probability of remission in dogs with higher glucose concentrations (odds ratio [OR], 1.2; P = .03) at diagnosis and longer time (weeks) from diagnosis to surgery (OR, 1.5; P = .05).Conclusions: Diabetes mellitus in Elkhounds develops mainly during diestrus and pregnancy. Immediate OHE improves the prognosis for remission of diabetes.