Copper-catalysed coupling of undec-10-enylmagnesium bromide with ω-functionalised halogenoalkanes as a key reaction for the synthesis of novel bipolar phospholipids with different head groups and chain length
Copper-catalysed coupling of undec-10-enylmagnesium bromide with ω-functionalised halogenoalkanes as a key reaction for the synthesis of novel bipolar phospholipids with different head groups and chain length
复制标题
铜催化十一烯基溴化镁与ω-官能化卤代烷的偶联作为合成具有不同头基和链长的新型双极磷脂的关键反应
DOI：
10.1039/a606855c
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
B. Dobner
中科院分区：
文献类型：
--
作者：
U. Heiser;B. Dobner
来自11-溴十一碳-1-烯的格氏试剂经历
铜催化的与ω-官能化卤代烷烃的偶联
不同的链长以提供长链ω-取代的
烯烃。对反应条件进行了优化，
产物产率，特别是用于制备
C32单元。官能化烯烃是合适的结构单元
用于直接合成具有不同头部的双极性磷脂
组
The Grignard reagent from 11-bromoundec-1-ene undergoes
copper-catalysed coupling with ω-functionalised halogenoalkanes of
different chain length to provide long-chain ω-substituted
alkenes. The reaction conditions for this have been studied to optimise
the products yields, especially those for the preparation of the
C32 unit. Functionalised alkenes are suitable building blocks
for the direct synthesis of bipolar phospholipids with different head
groups.