Mammalian lipoxygenases and their biological relevance.
Mammalian lipoxygenases and their biological relevance.
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DOI：
10.1016/j.bbalip.2014.10.002
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
van Leyen K
中科院分区：
文献类型：
--
作者：
Kuhn H;Banthiya S;van Leyen K
脂氧合酶（LOX）是一类异质性的脂质过氧化酶，不仅与细胞增殖和分化有关，而且与多种疾病的发病机制有关，与公共卫生有着重要的关系。与其他脂肪酸双加氧酶一样，LOX将多不饱和脂肪酸氧化成其相应的氢过氧衍生物，其进一步转化为生物活性脂质介质（类花生酸和相关物质）。另一方面，脂氧合酶是调节细胞氧化还原稳态的关键参与者，氧化还原稳态是基因表达调节的重要元件。虽然第一个哺乳动物脂肪氧合酶是在40年前发现的，尽管这些酶的结构和功能特性已经得到了很好的表征，但不同脂肪氧合酶亚型的生物学作用还没有完全了解。本文综述了哺乳动物LOX同工酶在炎症、代谢、过度增殖、神经退行性疾病和感染性疾病中的生理作用及其病理生理功能。
Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which have been implicated in cell proliferation and differentiation but also in the pathogenesis of various diseases with major public health relevance. As other fatty acid dioxygenases LOX oxidize polyunsaturated fatty acids to their corresponding hydroperoxy derivatives, which are further transformed to bioactive lipid mediators (eicosanoids and related substances). On the other hand, lipoxygenases are key players in regulation of the cellular redox homeostasis, which is an important element in gene expression regulation. Although the first mammalian lipoxygenases were discovered 40 years ago and although the enzymes have been well characterized with respect to their structural and functional properties the biological roles of the different lipoxygenase isoforms are not completely understood. This review is aimed at summarizing the current knowledge on the physiological roles of different mammalian LOX-isoforms and their patho-physiological function in inflammatory, metabolic, hyperproliferative, neurodegenerative and infectious disorders.
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影响因子：
9.7
作者：
Belfiore, Maria Cristina;Natoni, Alessandro;Gualandi, Giamplero
通讯作者：
Gualandi, Giamplero
DOI：
10.1016/0005-2760(70)90086-x
发表时间：
1970-01-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
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通讯作者：
Belayev, Ludmila
影响因子：
4.8
作者：
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