Psychometric Evaluation of the Kansas City Cardiomyopathy Questionnaire in Men and Women With Heart Failure.
Psychometric Evaluation of the Kansas City Cardiomyopathy Questionnaire in Men and Women With Heart Failure.
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DOI：
10.1161/circheartfailure.120.008284
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发表时间：
2021-09
期刊：
影响因子：
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通讯作者：
Spertus JA
中科院分区：
文献类型：
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作者：
Hejjaji V;Tang Y;Coles T;Jones PG;Reeve BB;Mentz RJ;Spatz ES;Dunlay SM;Caldwell B;Saha A;Tarver ME;Tran A;Patel KK;Henke D;Piña IL;Spertus JA
堪萨斯城心肌病问卷（KCCQ）已在多发性心力衰竭（HF）人群中进行了心理测量学评估，但其心理测量特性在男性和女性之间的可比性尚不清楚。3项临床试验[1项针对稳定型HF并保留射血分数（HFpEF）， 1项针对稳定型和急性型HF并降低射血分数（HFrEF）]和1项前瞻性队列研究（稳定型HFrEF），纳入6773名男性和3612名女性HF患者，数据用于比较两性之间的结构效度、内部和重测信度、检测变化、预测死亡率和住院率的能力以及最小重要差异（MIDs）。KCCQ总体总结（OS）和按性别划分的子域得分的相互作用是独立的。在稳定型（男性- 0.40 vs女性- 0.49）和急性型（男性- 0.37 vs女性- 0.34）心衰患者中，KCCQ-OS评分与纽约心脏协会功能分级均有良好的相关性。在21个结构效度分析中，有19个KCCQ子域与相关的比较标准表现出一致的关系，在性别上没有显著的相互作用。所有的KCCQ分数都具有同样的预测性，其他的心理测量评估也显示了类似的性别结果：测试-再测试信度（男性的班级内相关系数为0.94，女性为0.92），对变化的反应（男女的标准化反应平均为1.01），mid和内部信度也是如此。在HFpEF和HFrEF的男性和女性中，KCCQ的心理测量特性在效度、预后、信度和变化敏感性方面具有可比性。
The Kansas City Cardiomyopathy Questionnaire (KCCQ) has been psychometrically evaluated in multiple heart failure (HF) populations, but the comparability of its psychometric properties between men and women is unknown. Data from 3 clinical trials [1 in stable HF with preserved ejection fraction (HFpEF), 1 each in stable and acute HF with reduced ejection fraction (HFrEF)] and 1 prospective cohort study (stable HFrEF), incorporating 6773 men and 3612 women with HF, were used to compare the construct validity, internal and test-retest reliability, ability to detect change, predict mortality and hospitalizations and minimally important differences (MIDs) between the two genders. Interactions of the KCCQ overall summary (OS) and subdomain scores by gender were independently examined. The KCCQ-OS score correlated well with New York Heart Association functional class in both genders across patients with stable (correlation coefficient: −0.40 in men vs −0.49 in women) and acute (−0.37 in men vs −0.34 in women) HF. All KCCQ subdomains demonstrated concordant relationships with relevant comparison standards with no significant interactions by sex in 19 of 21 of these construct validity analyses. All KCCQ scores were equally predictive and other psychometric evaluations showed similar results by gender: test-retest reliability (Intra-class correlation coefficient 0.94 in men vs. 0.92 in women), responsive to change (Standardized response mean 1.01 in both genders), as were the MIDs and internal reliability. The psychometric properties of the KCCQ, in terms of validity, prognosis, reliability and sensitivity to change are comparable, in men and women with HFpEF and HFrEF.