Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases.

Metabolic profiling of follistatin overexpression: a novel therapeutic strategy for metabolic diseases.
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DOI：
10.2147/dmso.s159315
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发表时间：
2018
期刊：
Diabetes, metabolic syndrome and obesity : targets and therapy
影响因子：
--
通讯作者：
Reddy ST
Reddy ST
中科院分区：
其他
文献类型：
--
作者：
Singh R;Pervin S;Lee SJ;Kuo A;Grijalva V;David J;Vergnes L;Reddy ST
来源链接：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875402/

文献摘要

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Follistatin (Fst) promotes brown adipocyte characteristics in adipose tissues. Abdominal fat volume (CT scan), glucose clearance (GTT test), and metabolomics analysis (mass spectrometry) of adipose tissues from Fst transgenic (Fst-Tg) and wild type (WT) control mice were analyzed. Oxygen consumption (Seahorse Analyzer) and lipidomics (gas chromatography) was analyzed in 3T3-L1 cells. Fst-Tg mice show significant decrease in abdominal fat content, increased glucose clearance, improved plasma lipid profiles and significant changes in several conventional metabolites compared to the WT mice. Furthermore, overexpression of Fst in 3T3-L1 cells resulted in up regulation of key brown/beige markers and changes in lipidomics profiles. Fst modulates key factors involved in promoting metabolic syndrome and could be used for therapeutic intervention.