Automated eligibility screening and monitoring for genotype-driven precision oncology trials
Automated eligibility screening and monitoring for genotype-driven precision oncology trials
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DOI：
10.1093/jamia/ocw020
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发表时间：
2016-07-01
影响因子：
6.4
通讯作者：
Stetson, Peter D.
中科院分区：
文献类型：
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作者：
Eubank, Michael H.;Hyman, David M.;Stetson, Peter D.
纪念斯隆凯特琳癌症中心的信息系统部门开发了达尔文队列管理系统（DCMS）。DCMS根据基因型和临床数据识别和跟踪患者队列。它帮助研究人员和治疗医生招募患者参加基因型匹配的IRB批准的临床试验。DCMS在用户即将进行的预约之前向其发送自动化、可操作且安全的电子邮件通知，其中包含有关合格或已登记患者的信息。该系统还通过对患者资格的注释和对未来状态更新的偏好来捕获研究者输入。截至2015年8月，DCMS正在跟踪临床手术和研究队列中的159，893名患者。已建立134个研究队列，并跟踪64，473名患者。其中51，192人进行了一项或多项基因组测试，包括MSK-IMPACT，包括有资格进行基因型匹配研究的人群。本文介绍了此信息学解决方案的设计和发展。
The Information Systems Department at Memorial Sloan Kettering Cancer Center developed the DARWIN Cohort Management System (DCMS). The DCMS identifies and tracks cohorts of patients based on genotypic and clinical data. It assists researchers and treating physicians in enrolling patients to genotype-matched IRB-approved clinical trials. The DCMS sends automated, actionable, and secure email notifications to users with information about eligible or enrolled patients before their upcoming appointments. The system also captures investigators input via annotations on patient eligibility and preferences on future status updates. As of August 2015, the DCMS is tracking 159,893 patients on both clinical operations and research cohorts. 134 research cohorts have been established and track 64,473 patients. 51,192 of these have had one or more genomic tests including MSK-IMPACT, comprising the pool eligible for genotype-matched studies. This paper describes the design and evolution of this Informatics solution.