Prevalence, severity and correlates of fatigue in newly diagnosed patients with myelodysplastic syndromes
Prevalence, severity and correlates of fatigue in newly diagnosed patients with myelodysplastic syndromes
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DOI：
10.1111/bjh.13138
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发表时间：
2015-02-01
影响因子：
6.5
通讯作者：
Mandelli, Franco
中科院分区：
文献类型：
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作者：
Efficace, Fabio;Gaidano, Gianluca;Mandelli, Franco
本研究的主要目的是调查与新诊断的高危骨髓增生异常综合征（MDS）患者疲劳严重程度相关的因素。次要目的是评估这些患者的症状患病率，并检查疲劳、生活质量（QoL）和总体症状负担之间的关系。这些分析在280名高危MDS患者中进行。使用慢性疾病治疗功能评估（FACIT）-疲劳量表评价治疗前患者报告的疲劳，使用欧洲癌症研究与治疗组织生活质量量表-核心30（EORTC QLQ-C30）评估QoL。女性（P= 0.018），体能状态差（即，ECOG 2-4）（P
The primary objective of this study was to investigate factors associated with fatigue severity in newly diagnosed patients with higher-risk myelodysplastic syndromes (MDS). The secondary objectives were to assess symptom prevalence and to examine the relationships between fatigue, quality of life (QoL) and overall symptom burden in these patients. The analyses were conducted in 280 higher-risk MDS patients. Pre-treatment patient-reported fatigue was evaluated with the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale and QoL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). Female gender (P=0018), poor performance status (i.e., ECOG of 2-4) (P