BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia
BCOR mutation and TLS-ERG expression in acute myeloid leukemia with monoclonal immunoglobulinemia
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DOI：
10.2147/ott.s218805
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发表时间：
2019-01-01
影响因子：
4
通讯作者：
Huang, Jian
中科院分区：
文献类型：
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作者：
Jin, Jingxia;Luo, Shuna;Huang, Jian
急性髓系白血病（acute myeloid leukemia，AML）起源于成髓细胞的异常克隆性增殖。免疫球蛋白由B细胞分泌。AML单克隆抗体阳性常提示预后不良。在此我们报告一例急性髓细胞白血病合并单克隆免疫球蛋白血症的BCOR突变和TLS-ERG表达。化疗后，患者达到骨髓完全缓解，患者骨髓中未检测到BCOR突变和TLS-ERG融合基因，同时，外周血单克隆免疫球蛋白也消失。BCOR突变或TLS-ERG融合基因表达与预后不良相关，AML伴单克隆免疫球蛋白表达可能具有相同的预后意义。
Acute myeloid leukemia (AML) originates from the abnormal clonal proliferation of myeloblasts. Immunoglobulin is secreted by B cells. AML with monoclonal antibody often indicates a poor prognosis. Here we report a case of BCOR mutation and TLS-ERG expression in AML with monoclonal immunoglobulinemia. After chemotherapy, the patient achieved bone marrow complete remission BCOR mutation and TLS-ERG fusion gene in patient's bone marrow were not detected, at the same time, peripheral blood monoclonal immunoglobulin also disappeared. BCOR mutation or TLS-ERG fusion gene expression is associated with poor prognosis, AML with monoclonal immunoglobulin may have the same prognostic significance.