Evaluation of the effects of various chemicals on discharge of and pain caused by jellyfish nematocysts
Evaluation of the effects of various chemicals on discharge of and pain caused by jellyfish nematocysts
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DOI：
10.1016/j.cbpc.2010.01.007
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发表时间：
2010-05-01
影响因子：
3.9
通讯作者：
Lee, Richard F.
中科院分区：
文献类型：
--
作者：
Birsa, Laura M.;Verity, Peter G.;Lee, Richard F.
水母的触须与人体皮肤接触时会产生疼痛、肿胀和发红，这种疼痛是由于水母分泌线虫包囊和相关毒素，并由各种机械和化学刺激引起的。研究人员用传统上用于治疗水母叮咬的化学物质，如醋酸氨、肉类嫩化剂、小苏打和尿素进行了一系列测试，以确定这些化学物质是刺激还是抑制线囊分泌，以及它们是否能缓解暴露在水母触角下的测试者的痛苦。研究中使用了五叶锦葵(海燕)、海蜂(海蜂)和酸浆(葡萄牙军舰)。研究发现，许多传统上用于治疗水母叮咬的化学物质会刺激线虫囊排出，并不能缓解疼痛。然而，当普通麻醉剂利多卡因喷洒在与水母触须接触的测试者的皮肤上时，立即得到了缓解。最初将触角悬浮液暴露于利多卡因可通过随后暴露于醋酸、乙醇、氨或菠萝酶来阻止线虫囊排出，因此，除了在皮肤上充当与水母触须接触的麻醉剂外，利多卡因还可能通过阻断线虫细胞的钠和/或钙通道来抑制线虫囊排出。(C)2010 Elsevier Inc.版权所有
Jellyfish tentacles in contact with human skin can produce pain swelling and redness The pain is due to discharge of jellyfish nematocysts and associated toxins and discharge can be caused by a variety of mechanical and chemical stimuli. A series of tests were carried out with chemicals traditionally used to treat Jellyfish stings e g acetic acid ammonia meat tenderizer baking soda and urea to determine if these chemicals stimulated or inhibited nematocyst discharge and if they brought relief to testers who were exposed to jellyfish tentacles Chrysaora quinquecirrha (sea nettle) Chiropsalmus quadrumanus (sea wasp) and Physalia physalis (Portuguese man-of-war) were used in the study. It was found that many of the chemicals traditionally used to treat jellyfish stings stimulated nematocyst discharge and did not relieve the pain. However there was immediate relief when a common anesthetic lidocaine was sprayed on the skin of testers in contact with jellyfish tentacles. Initial exposure of tentacle suspensions to lidocaine prevented the nematocyst discharge by subsequent exposure to acetic acid ethanol ammonia or bromelain Thus lidocaine in addition to acting as an anesthetic on skin in contact with jellyfish tentacles inhibited nematocyst discharge possibly by blocking sodium and/or calcium channels of the nematocytes. (C) 2010 Elsevier Inc All rights reserved