Failing in Parkinson disease - Identifying and prioritizing risk factors in recurrent fallers
Failing in Parkinson disease - Identifying and prioritizing risk factors in recurrent fallers
复制标题
DOI：
10.1097/phm.0b013e311611583
复制
发表时间：
2007-08-01
影响因子：
3
通讯作者：
Stern, Matthew B.
中科院分区：
文献类型：
--
作者：
Dennison, Andrew C.;Noorigian, Joseph V.;Stern, Matthew B.
目的：为了确定下降的危险因素在一个研究人群中的复发性跌倒者相比，nonfallers谁有帕金森病，并优先考虑下降的危险因素，在这个患者群体中，以针对他们modification.Design：23个复发性跌倒者和25 nonfallers谁有帕金森病被招募，他们参加了一个全面的评估，探测下降的危险因素的存在。为了确定跌倒的危险因素，采用组比较设计，在一系列变量中比较复发性跌倒者和非跌倒者。优先使用递归分区建模进行，这些风险因素，进入模型下降，风险因素在本研究和其他研究中被认为是潜在的modifiable.Results：一个特定的变量特征区分谁在我们的研究人群中帕金森病复发跌倒：疾病严重程度较高，运动障碍程度较高，残疾程度较高，腿部敏捷性或下肢协调性受损，从椅子上起身的能力受损或近端下肢运动控制受损、上肢功能受损、手脚运动规划受损、动态平衡受损（通过一前一后行走的能力测量）和害怕跌倒。递归分区优先考虑三个风险因素：受损的amorphous，受损的下肢运动规划，和orthostasis.Conclusions：在这项研究中，一个特异质的失败的风险因素的配置文件被证明在我们的受试者谁有帕金森病。三个变量被优先考虑为潜在的修改：受损的上肢，受损的下肢运动规划，和体位。
Objectives: To identify falling risk factors in a study population of recurrent fallers compared with nonfallers who have Parkinson disease, and to prioritize falling risk factors in this patient population to target them for modification.Design: Twenty-three recurrent fallers and 25 nonfallers who have Parkinson disease were recruited, and they participated in a comprehensive assessment probing for the presence of falling risk factors. To identify falling risk factors, a group comparative design was used to compare recurrent fallers and nonfallers across an array of variables. To prioritize modeling using recursive partitioning was performed, those risk factors, entering into the model falling, risk factors identified in this and other studies that were considered potentially modifiable.Results: A specific profile of variables distinguished recurrent fallers who have Parkinson disease in our study population: higher disease severity, higher level of motor impairment, higher level of disability, impaired leg agility or lower-limb coordination, impaired ability to arise from a chair or compromised proximal lower-limb motor control, impaired ambulation, impaired motor planning of the hands and feet, impaired dynamic balance as measured by ability to walk in tandem, and fear of falling. Recursive partitioning prioritized three risk factors: impaired ambulation, impaired lower-limb motor planning, and orthostasis.Conclusions: In this study, an idiosyncratic failing risk factor profile was demonstrated among our subjects who have Parkinson disease. Three variables were prioritized for potential modification: impaired ambulation, impaired lower-limb motor planning, and orthostasis.