Correlation of Regional Cerebral Blood Flow (rCBF) with EEG Changes During Isoflurane Anesthesia for Carotid Endarterectomy: Critical rCBF
Correlation of Regional Cerebral Blood Flow (rCBF) with EEG Changes During Isoflurane Anesthesia for Carotid Endarterectomy: Critical rCBF
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DOI：
10.1097/00000542-198703000-00014
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发表时间：
1987-03
期刊：
影响因子：
8.8
通讯作者：
J. Messick;B. Casement;F. Sharbrough;L. N. Milde;J. Michenfelder;T. Sundt
中科院分区：
文献类型：
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作者：
J. Messick;B. Casement;F. Sharbrough;L. N. Milde;J. Michenfelder;T. Sundt
应用~(133)Xe清除技术对31例ASA P.S.II-III级颈动脉内膜剥脱术患者的局部脑血流量(RCBF)(同侧大脑中动脉分布)进行了前瞻性评价。在麻醉和手术过程中，每个患者都接受了16通道脑电监测。临界rCBF被定义为脑电缺血征象出现的流量以下的流量。6例手术颈动脉临时阻断时出现一过性脑电改变的患者，其临界局部脑血流量(T1/2法)为10ml·100g~(-1)min−_1(平均值±SE5.9±1.2)。另25例闭塞患者无脑电改变，平均(±SE)闭塞rCBF为18.9±1.3ml.100g−1.min−1(P<；0.001)。闭塞前血流在两组间无显著差异。异氟醚麻醉时的临界局部脑血流量小于氟烷麻醉时的临界值(18~20ml.100g−1.min−1)，与异氟醚对脑血流量的影响一致。
A prospective evaluation of regional cerebral blood flow (rCBF) (ipsilateral middle cerebral artery distribution) was determined using a 133Xe clearance technique in 31 ASA P.S. II–III patients anesthetized with isoflurane-50% N2O in O2 for carotid endarterectomy. Each patient was monitored with 16-channel EEG throughout anesthesia and surgery. Critical rCBF was defined as that flow below which EEG signs of ischemia occurred. Critical rCBF (T1/2 method of analysis) was <10 ml.100 g-1.min−1 (mean ± SE 5.9 ± 1.2) in the six patients in whom transient EEG changes occurred at the time of temporary surgical carotid artery occlusion. No EEG changes occurred with occlusion in the other 25 patients; mean (±SE) occlusion rCBF in this group was 18.9 ± 1.3 ml.100 g−1.min−1 (P <0.001). Preocclusion flows were not significantly different in the two groups. Critical rCBF during isoflurane anesthesia was less than that previously determined during halothane anesthesia (18–20 ml.100 g−1.min−1), and is compatible with the effects of isoflurane on CMRo2 and CBF.