Influencing Factors of Thermogenic Adipose Tissue Activity.
Influencing Factors of Thermogenic Adipose Tissue Activity.
复制标题
产热脂肪组织活性的影响因素。
DOI：
10.3389/fphys.2016.00029
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发表时间：
2016
影响因子：
4
通讯作者：
Liu C
中科院分区：
文献类型：
--
作者：
Zhang G;Sun Q;Liu C
肥胖是一个不断升级的公共卫生挑战，并对全球疾病负担造成巨大影响。需要新的治疗策略来减轻肥胖相关代谢功能障碍对健康的影响。棕色脂肪组织(BAT)是专门用于散热的化学能量，以抵御寒冷的环境。有趣的是，分布在啮齿动物和人类白色脂肪组织(WAT)中的棕色脂肪样脂肪细胞，被称为“棕色”或“米色”脂肪细胞，与棕色脂肪细胞具有相似的生热特征。最近，研究人员开始关注对这些生热脂肪组织的认识。目前已发现一些调节生热脂肪组织发育和功能的因子。冷暴露、药物条件和生活方式可以通过某些机制增强非颤抖的产热和代谢。然而，环境污染物，如环境中的细颗粒物和臭氧，可能会损害这些生热脂肪组织的功能，从而导致代谢功能障碍。本文综述了生热脂肪组织的起源、功能及影响因素，为寻找治疗肥胖及肥胖相关疾病的新策略提供参考。
Obesity is an escalating public health challenge and contributes tremendously to the disease burden globally. New therapeutic strategies are required to alleviate the health impact of obesity-related metabolic dysfunction. Brown adipose tissue (BAT) is specialized for dissipating chemical energy for thermogenesis as a defense against cold environment. Intriguingly, the brown-fat like adipocytes that dispersed throughout white adipose tissue (WAT) in rodents and humans, called “brite” or “beige” adipocytes, share similar thermogenic characteristics to brown adipocytes. Recently, researchers have focused on cognition of these thermogenic adipose tissues. Some factors have been identified to regulate the development and function of thermogenic adipose tissues. Cold exposure, pharmacological conditions, and lifestyle can enhance non-shivering thermogenesis and metabolism via some mechanisms. However, environmental pollutants, such as ambient fine particulates and ozone, may impair the function of these thermogenic adipose tissues and thereby induce metabolic dysfunction. In this review, the origin, function and influencing factors of thermogenic adipose tissues were summarized and it will provide insights into identifying new therapeutic strategies for the treatment of obesity and obesity-related diseases.