Effect of dietary fat composition on the metabolism of triacylglycerol-rich plasma lipoproteins in the postprandial phase in meal-fed rats.
Effect of dietary fat composition on the metabolism of triacylglycerol-rich plasma lipoproteins in the postprandial phase in meal-fed rats.
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膳食脂肪成分对膳食喂养大鼠餐后阶段富含三酰甘油的血浆脂蛋白代谢的影响。
DOI：
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发表时间：
1988
影响因子：
6.5
通讯作者：
W. C. Hülsmann
中科院分区：
文献类型：
--
作者：
P. Groot;B. D. de Boer;E. Haddeman;U. Houtsmuller;W. C. Hülsmann
大鼠习惯于进食固定大小的膳食(上午7点和下午7点)，食用富含棕榈油或葵花籽油的日粮，研究餐后乳糜粒和肝脏极低密度脂蛋白(VLDL)代谢随时间的变化。与喂食葵花籽油的大鼠相比，喂食棕榈油的大鼠在餐前7时的血清三酰甘油水平更高(1.96+/-0.25 mM比1.09+/-0.09 mM)，餐后达到更高的水平(4.32+/-0.48 mM比2.87+/-0.18 mM)，这是因为肝脏VLDL水平更高(上午7点)，乳糜粒和肝脏VLDL水平更高(餐后阶段)。被测试的两种饮食之间血清三酰甘油浓度的差异被发现不是由于肝脏VLDL三酰甘油分泌的差异(两种饮食组的三酰甘油分泌速度相似，受膳食摄入量的影响不大)，也不是由于乳清三酰甘油分泌的差异(两种饮食的反应曲线相似)，而是血浆三酰甘油分解代谢的差异。随后对喂食棕榈油和葵花籽油的受试者的乳胶粒的三酰甘油分解代谢的双标记研究表明，棕榈油三酰甘油的分解代谢比葵花籽油的三酰甘油慢。此外，喂食葵花籽油的动物的肝素后血浆脂蛋白脂酶活性有升高的趋势。根据这些数据，我们得出结论，在棕榈油喂养的动物中发现的相对高甘油三酯血症是由于分解代谢效率较低，而不是由于血浆三酰甘油合成增加。
Rats conditioned to eating fixed-size meals (meals at 7 AM and 7 PM), consuming diets rich in palm oil or sunflower seed oil, were used to study the metabolism of chylomicrons and hepatic very low density lipoproteins (VLDL) as a function of time after meal consumption. Rats fed a palm oil diet had higher serum triacylglycerol levels at 7 AM, before the meal (1.96 +/- 0.25 mM vs. 1.09 +/- 0.09 mM) and reached higher levels postprandially (4.32 +/- 0.48 mM vs. 2.87 +/- 0.18 mM) than sunflower seed oil-fed animals, due to higher levels of hepatic VLDL (at 7 AM) and higher levels of chylomicrons and hepatic VLDL (in the postprandial phase). These differences in serum triacylglycerol concentrations between the diets tested were found not to be due to differences in hepatic VLDL triacylglycerol secretion (similar rate for both dietary groups and not very much affected by meal consumption) or chylomicron triacylglycerol secretion (similar response profiles on both diets), pointing towards differences in plasma triacylglycerol catabolism. Subsequent double-label studies on triacylglycerol catabolism of chylomicrons from palm oil- and sunflower seed oil-fed animals in chow-fed recipients showed that palm oil triacyglycerol is catabolized slower than sunflower seed oil triacylglycerol. Furthermore, activities of postheparin plasma lipoprotein lipase tended to be higher in sunflower seed oil-fed animals. From these data we conclude that the relative hypertriglyceridemia found in palm oil-fed animals is due to less efficient catabolism and not to increased synthesis of plasma triacylglycerol.
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DOI：
--
发表时间：
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期刊：
The Journal of biological chemistry
影响因子：
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作者：
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影响因子：
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