Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties
Bisphosphonate treatment affects trabecular bone apparent modulus through micro-architecture rather than matrix properties
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DOI：
10.1016/j.orthres.2003.05.001
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发表时间：
2004-05-01
影响因子：
2.8
通讯作者：
Weinans, H
中科院分区：
文献类型：
--
作者：
Day, JS;Ding, M;Weinans, H
双磷酸盐类药物正在成为骨质疏松症的重要治疗药物。但是，双膦酸盐治疗相关的骨折风险降低是否是由于骨量增加、骨小梁结构改善和/或钙化基质继发性矿化增加仍不清楚。我们研究了双膦酸盐对犬松质骨的小梁结构和基质性质的影响。将36只比格犬分为对照组和两个治疗组，一个治疗组接受利塞膦酸钠治疗，另一个治疗组接受阿仑膦酸钠治疗，剂量为骨质疏松症临床剂量的5-6倍。一年后，将狗杀死，并使用显微计算机断层扫描，有限元建模和机械测试的组合检查第一腰椎的样本。通过结合这些方法，我们独立地检查了对钙化基质和小梁结构的治疗效果。从相同犬的第二和第三腰椎中获得常规组织形态学和微损伤数据[Bone 28（2001）524]。双膦酸盐治疗导致表观杨氏模量增加，骨转换降低，钙化基质密度增加，微损伤增加。在双膦酸盐处理组中，我们无法检测到钙化基质的有效杨氏模量的任何变化。观察到的表观杨氏模量增加是由于骨量增加和骨小梁结构改变，而不是钙化基质模量的变化。我们假设由于钙化基质密度增加而导致的钙化基质杨氏模量的预期增加被微损伤的积累所抵消。(C)2003骨科研究学会。由爱思唯尔有限公司出版。保留所有权利。
Bisphosphonates are emerging as an important treatment for osteoporosis. But whether the reduced fracture risk associated with bisphosphonate treatment is due to increased bone mass, improved trabecular architecture and/or increased secondary mineralization of the calcified matrix remains unclear. We examined the effects of bisphosphonates on both the trabecular architecture and matrix properties of canine trabecular bone. Thirty-six beagles were divided into a control group and two treatment groups, one receiving risedronate and the other alendronate at 5-6 times the clinical dose for osteoporosis treatment. After one year, the dogs were killed, and samples from the first lumbar vertebrae were examined using a combination of micro-computed tomography, finite element modeling, and mechanical testing. By combining these methods, we examined the treatment effects on the calcified matrix and trabecular architecture independently. Conventional histomorphometry and microdamage data were obtained from the second and third lumbar vertebrae of the same dogs [Bone 28 (2001) 524]. Bisphosphonate treatment resulted in an increased apparent Young's modulus, decreased bone turnover, increased calcified matrix density, and increased microdamage. We could not detect any change in the effective Young's modulus of the calcified matrix in the bisphosphonate treated groups. The observed increase in apparent Young's modulus was due to increased bone mass and altered trabecular architecture rather than changes in the calcified matrix modulus. We hypothesize that the expected increase in the Young's modulus of the calcified matrix due to the increased calcified matrix density was counteracted by the accumulation of microdamage. (C) 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.