Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.
Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.
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DOI：
10.3390/toxins9010038
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发表时间：
2017-01-18
期刊：
影响因子：
4.2
通讯作者：
Stringer SC
中科院分区：
文献类型：
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作者：
Peck MW;Smith TJ;Anniballi F;Austin JW;Bano L;Bradshaw M;Cuervo P;Cheng LW;Derman Y;Dorner BG;Fisher A;Hill KK;Kalb SR;Korkeala H;Lindström M;Lista F;Lúquez C;Mazuet C;Pirazzini M;Popoff MR;Rossetto O;Rummel A;Sesardic D;Singh BR;Stringer SC
植物神经毒素是多种蛋白质。它们目前至少有7种血清型和40多种亚型。产生新型神经毒素变体的新梭菌菌株被鉴定的频率越来越高，这在组织围绕这些神经毒素的命名时提出了挑战。在世界范围内，研究人员面临着这样的可能性，即具有相同序列的毒素可能被赋予不同的名称，或者具有独特序列的新型毒素可能在出版时被赋予相同的名称。为了尽量减少这些问题，一个由肉毒杆菌神经毒素研究领域的20多名研究人员组成的特设委员会召开会议，讨论肉毒杆菌神经毒素命名所涉及的问题的澄清。本出版物提出了一个历史的问题，并在未来的肉毒杆菌神经毒素亚型命名提供了指导方针。
Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which presents challenges when organizing the nomenclature surrounding these neurotoxins. Worldwide, researchers are faced with the possibility that toxins having identical sequences may be given different designations or novel toxins having unique sequences may be given the same designations on publication. In order to minimize these problems, an ad hoc committee consisting of over 20 researchers in the field of botulinum neurotoxin research was convened to discuss the clarification of the issues involved in botulinum neurotoxin nomenclature. This publication presents a historical overview of the issues and provides guidelines for botulinum neurotoxin subtype nomenclature in the future.