CD30 + Primary intestinal T-cell lymphoma (unclassified) masquerading as chronic inflammation: a case report.
CD30 + Primary intestinal T-cell lymphoma (unclassified) masquerading as chronic inflammation: a case report.
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DOI：
10.1186/s13000-022-01237-0
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发表时间：
2022-06-25
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
原发性肠道T细胞淋巴瘤是一种罕见的恶性肿瘤，造成了诊断的困境，因为临床特征和影像学表现通常与炎症性肠病中遇到的重叠。当前的临床病例报告描述了一名具有非特异性胃肠道症状的患者的临床病史、实验室检查结果和组织病理学分析，该患者被推定为炎症性肠病的临床诊断，以及两份具有非特异性结果的肠道活检标本。由于持续的症状，第三次活检与原发性肠道T细胞淋巴瘤一致，这是一个在最初表现后数月难以诊断的诊断。需要临床与实验室和组织病理学结果的相关性来建立明确的诊断并进一步对患者进行分层。此外，肿瘤细胞的特点是部分表达CD30，这具有相关的治疗意义。对于有持续腹部症状而无明确病因的患者，应始终怀疑肠道T细胞淋巴增生性疾病。目前的讨论提供了一个总结和审查的主要诊断组织学特征的分类原发性肠道T细胞淋巴瘤。此外，讨论描述了如何具体的组织学结果是相关的临床管理决策。
Primary intestinal T-cell lymphomas are uncommon malignancies that pose a diagnostic dilemma, because the clinical features and imaging findings commonly overlap with those encountered in inflammatory bowel diseases. The current clinical case report describes the clinical history, laboratory findings and histopathological analysis from a patient with non-specific gastrointestinal symptoms with a presumptive clinical diagnosis of inflammatory bowel disease, and two intestinal biopsy specimens with non-specific findings. Due to the persistent symptoms a third biopsy was consistent with primary intestinal T-cell lymphoma, a diagnosis that was elusive for months after the initial presentation. Clinical correlation with laboratory and histopathological findings is required to establish a definitive diagnosis and to further stratify the patients. In addition, the neoplastic cells featured partial expression of CD30, which had relevant therapeutic implications. Suspicion for an intestinal T-cell lymphoproliferative disorder should always exist in patients with persistent abdominal symptoms with no clear etiology. The current discussion provides a summary and review of the key diagnostic histological features for the classification of primary intestinal T-cell lymphomas. In addition, the discussion describes how specific the histological findings are relevant for the clinical management decisions.
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