Superiority of salt restriction over diuretics in reducing renal hypertrophy and injury in uninephrectomized SHR.
Superiority of salt restriction over diuretics in reducing renal hypertrophy and injury in uninephrectomized SHR.
复制标题
在未肾切除的 SHR 中，限盐在减少肾肥大和损伤方面优于利尿剂。
DOI：
10.1152/ajprenal.1990.258.6.f1675
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Dworkin,LD
中科院分区：
文献类型：
--
作者：
Benstein,JA;Feiner,HD;Parker,M;Dworkin,LD
自发性高血压大鼠（SHR）在6周龄时未切除肾脏（UNX），给予标准饲料（CON）、低钠饲料（LSC）或标准饲料和添加氢氯噻嗪（HCTZ）的饮用水。三组患者均出现严重高血压。UNX术后42周，LSC组蛋白尿和肾小球硬化明显低于CON或HCTZ组。限制盐的保护作用不依赖于血浆肾素浓度或肾小球血流动力学的改变。显微穿刺显示三组肾小球压力均较高。通过肾脏重量、肾体重比、肾小球体积和肾小球毛细血管半径评估的肾肥大通过限盐减少。这些发现表明，在肾小球高血压的情况下，肥大促进硬化。盐限制抑制代偿性肾脏生长和保护肾脏。
Spontaneously hypertensive rats (SHR) were uninephrectomized (UNX) at 6 wk of age and given either standard chow (CON), low-sodium chow (LSC), or standard chow and hydrochlorothiazide (HCTZ) added to the drinking water. Severe hypertension developed in all three groups. Forty-two weeks after UNX, proteinuria and glomerular sclerosis were significantly lower in LSC than in CON or HCTZ. The protective effect of salt restriction did not depend upon alterations in plasma renin concentration or glomerular hemodynamics. Micropuncture revealed that glomerular pressure was high in all three groups. Renal hypertrophy assessed by kidney weight, kidney-to-body weight ratio, glomerular volume, and glomerular capillary radius were reduced by salt restriction. These findings suggest that, in the setting of glomerular hypertension, hypertrophy promotes sclerosis. Salt restriction inhibits compensatory kidney growth and protects the kidney.