Activations related to "mirror" and "canonical" neurones in the human brain:: an fMRI study
Activations related to "mirror" and "canonical" neurones in the human brain:: an fMRI study
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DOI：
10.1016/s1053-8119(03)00042-9
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发表时间：
2003-04-01
期刊：
影响因子：
5.7
通讯作者：
Passingham, RE
中科院分区：
文献类型：
--
作者：
Grèzes, J;Armony, JL;Passingham, RE
在猕猴的腹侧运动前皮质(F5)中，当猴子观察到一个物体并抓住那个物体时，“典型神经元”是活跃的。在同一区域，当猴子观察到另一只猴子抓住一个物体时，以及当猴子抓住那个物体时，“镜像神经元”都会发出信号。我们使用事件相关功能磁共振成像来调查人类大脑中哪里可以发现反映典型和镜像神经元活动的激活。当受试者观察物体时，以及当他们对物体(经典神经元)做出反应时，顶内和中央前沟腹侧的肢体会被激活。当受试者观察手势(镜像神经元)时，在背侧运动前皮质、顶内皮质、顶盖(SII)和颞叶上沟有激活。最后，当受试者模仿手势并对物体做出反应时，腹侧运动前皮质和额叶下回(44区)的激活被发现。我们认为，在人脑中，中央前沟的腹侧支可能形成了猕猴F5区的一部分。44区有可能形成F5的前部，尽管解剖学研究表明它可能是运动前皮质和前额叶皮质之间的过渡区。(C)2003年埃尔塞维尔科学公司(美国)。版权所有。
In the macaque monkey ventral premotor cortex (F5), "canonical neurones" are active when the monkey observes an object and when the monkey grasps that object. In the same area, "mirror neurones" fire both when the monkey observes another monkey grasping an object and when the monkey grasps that object. We used event-related fMRI to investigate where in the human brain activation can be found that reflects both canonical and mirror neuronal activity. There was activation in the intraparietal and ventral limbs of the precentral sulcus when subjects observed objects and when they executed movements in response to the objects (canonical neurones). There was activation in the dorsal premotor cortex, the intraparietal cortex, the parietal operculum (SII), and the superior temporal sulcus when subjects observed gestures (mirror neurones). Finally, activations in the ventral premotor cortex and inferior frontal gyrus (area 44) were found when subjects imitated gestures and executed movements in response to objects. We suggest that in the human brain, the ventral limb of the precentral sulcus may form part of the area designated F5 in the macaque monkey. It is possible that area 44 forms an anterior part of F5, though anatomical studies suggest that it may be a transitional area between the premotor and prefrontal cortices. (C) 2003 Elsevier Science (USA). All rights reserved.