Central neurotransmitters and aging.
Central neurotransmitters and aging.
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中枢神经递质与衰老。
DOI：
10.1016/0024-3205(80)90172-1
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发表时间：
1980
期刊：
影响因子：
6.1
通讯作者：
S. Pradhan
中科院分区：
文献类型：
--
作者：
S. Pradhan
衰老被定义为“机体在成熟后逐渐退化”，不仅涉及随年龄增长的生理和生化变化，还涉及与年龄相关的病理发生频率的增加（19），例如帕金森病和老年痴呆症。虽然所有身体系统都表现出与年龄相关的变化，但中枢神经系统 (CNS) 在衰老过程中的行为和其他一些功能变化中起着主导作用。人类和动物研究表明，许多功能都与年龄相关，包括学习和短期记忆 (5, 62, 97, 98)、性活动 (18, 74)、食物摄入 (74)、睡眠 (74, 82)、动机和活动 (18)。已知其中许多功能受到下丘脑-垂体系统的调节，下丘脑-垂体系统会随着衰老而发生变化，并且在衰老过程的调节中强调了下丘脑-垂体系统的重要性（19）。为了将许多生理（包括行为）功能中与年龄相关的变化联系起来，针对中枢神经系统中几种神经递质的活性随衰老的变化进行了大量的神经化学研究，特别是多巴胺（DA）、去甲肾上腺素（NE）、血清素（5-羟色胺，5-HT）、乙酰胆碱（ACh）和γ氨基丁酸（GABA）。其中，对DA和NE的研究较为广泛。衰老对各种神经递质（特别是 DA 和 NE）的影响已在其代谢的各个阶段进行了研究，例如合成、储存、释放、受体作用、再摄取和生物转化（降解）。主要针对参与这些神经递质及其代谢物的合成、受体作用和降解的酶进行了大量研究，在中枢神经系统和其他组织的各个区域中的浓度和周转。
Aging has been defined as a" progressive deterioration of the organism after maturity" and involves not only physiological and biochemical changes with age, but also increasing frequency of age-related pathology (19), such as Parkinson's disease and senile dementia. While all physical systems show agerelated changes, those of the central nervous system (CNS) play a dominant role in behavioral and several other functional changes in aging. Human and animal studies have indicated age-related declines in many functions including learning and short-term memory (5, 62, 97, 98), sexual activity (18, 74), food intake (74), sleep (74, 82), motivation and activity (18). Many of these functions are known to be modulated by hypothalamus-pituitary system which undergoes changes with aging and importance of which has been emphasized in the regulation of aging process (19).With a view to correlate the age-related changes in many physiological (including behavioral) function, numerous neurochemical investigations have been conducted with respect to alterations with aging in the activity of several neurotransmitters in the CNS, specially dopamine (DA), norepinephrine (NE), serotonin (5-hydroxytryptamine, 5-HT), acetylcholine (ACh) and gamaaminobutyric acid (GABA). Of these, the studies on DA and NE have been comparatively more extensive. The effects of aging on the various neurotransmitters, particularly DA and NE have been investigated in respect to the various phases of their metabolism eg synthesis, storage, release, receptor action, reuptake and biotransformatian (degradation). Numerous studies have been made mainly with enzymes involved in synthesis, receptor action and degradation of these neurotransmitters as well as their metabolites, concentration and turnover in various areas of the CNS and also other tissues.
衰老和神经系统。
影响因子：
7.3
作者：
Mather,Mara
通讯作者：
Mather,Mara