Extraventricular anaplastic ependymoma with metastasis to scalp and neck
Extraventricular anaplastic ependymoma with metastasis to scalp and neck
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DOI：
10.1007/s11060-010-0525-x
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发表时间：
2011-09-01
影响因子：
3.9
通讯作者：
Kiehl, Tim-Rasmus
中科院分区：
文献类型：
--
作者：
Davis, Matthew J.;Hasan, Fauzia;Kiehl, Tim-Rasmus
我们报告一位22岁女性间变性室管膜瘤合并颅外转移的病例。患者最初表现为头痛和构音障碍。神经影像显示右侧额颞部有一个大的实性囊状病变。它完全位于脑室外，根据神经成像结果怀疑是胶质母细胞瘤。实现了大体全切除。组织病理学检查显示为间变性室管膜瘤。病人接受了放射治疗。初次手术约一年后，患者出现头皮转移性病变。2年后，发现腮腺内转移。随后的颈淋巴清扫术显示不同水平的阳性淋巴结。随后对颈部进行放射治疗。初次手术5年后，患者有残留的转移疾病。对此病例进行了讨论，并复习了有关室管膜外肿瘤的文献。
We report a case of anaplastic ependymoma with extracranial metastases in a 22-year-old female. The patient originally presented with headaches and dysarthria. Neuroimaging revealed a large solid and cystic right fronto-temporal lesion. It was located completely extraventricularly and a glioblastoma was suspected based on the neuroimaging findings. A gross total resection was achieved. Histopathologic examination revealed an anaplastic ependymoma. The patient was treated with radiotherapy. Approximately 1 year after the initial surgery, the patient presented with metastatic disease to the scalp. At 2 years, an intraparotid metastasis was detected. Subsequent neck dissection revealed positive lymph nodes at several levels. It was followed by radiotherapy to the neck. 5 years after the initial surgery, the patient has residual metastatic disease. The case is discussed and the literature on extraventricular ependymal neoplasms is reviewed.