Cardiorespiratory and anesthetic effects of propofol and thiopental in dogs.
Cardiorespiratory and anesthetic effects of propofol and thiopental in dogs.
复制标题
丙泊酚和硫喷妥钠对狗的心肺和麻醉作用。
DOI：
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发表时间：
1998
影响因子：
1
通讯作者：
M. Raffe
中科院分区：
文献类型：
--
作者：
Jane E. Quandt;Elaine P. Robinson;William J. Rivers;M. Raffe
目的
比较静脉注射异丙酚和硫喷妥钠对犬的心肺和麻醉作用。
动物
6只健康的杂种狗。
程序
用异氟烷麻醉每只犬，然后将热敏电阻导管插入肺动脉。恢复至少2.5小时后，将导管置于头静脉中，用于乳酸林格氏液和药物给药。在一项随机交叉设计研究中，对每只犬给予丙泊酚（8 mg/kg体重）或硫喷妥钠（19.4 mg/kg）。对所有犬进行插管，并允许自主呼吸100%氧气。心率和节律;在给药前和给药前10分钟内每2分钟，然后在给药后15、30和60分钟测量收缩压、舒张压和平均动脉压;呼吸率;潮气末二氧化碳浓度;潮气量;和反射（趾蹼收缩、眼睑反应和下颌张力）。在0、2、6、10、15、30和60分钟时测定心输出量，并在0、2、10和30分钟时收集血液样本。记录气管内拔管时间、抬头时间以及无辅助坐立和行走能力。
结果
给药后，每组6只犬中有3只出现呼吸暂停。两种麻醉剂的反射降低相似，但未完全丧失。丙泊酚组胸骨位和独立行走的时间明显缩短。
结论
麻醉是迅速的，然而，呼吸抑制和呼吸暂停是与丙泊酚和硫喷妥钠相关的主要不良反应。异丙酚具有麻醉恢复迅速、协调的优点。
OBJECTIVE
To compare cardiorespiratory and anesthesia effects of IV administered propofol and thiopental in dogs.
ANIMALS
6 healthy mixed-breed dogs.
PROCEDURE
Each dog was anesthetized with isoflurane, then a thermistor catheter was inserted in the pulmonary artery. After a minimum of 2.5 hours of recovery, a catheter was placed in a cephalic vein for administration of lactated Ringer's solution and drugs. Propofol (8 mg/kg of body weight) or thiopental (19.4 mg/kg) was administered to each dog in a randomized crossover design study. All dogs were intubated and allowed to breathe 100% oxygen spontaneously. Heart rate and rhythm; systolic, diastolic, and mean arterial blood pressures; respiratory rate; end-tidal carbon dioxide concentration; tidal volume; and reflexes (toe web pinch, palpebral response, and jaw tone) were measured before and every 2 minutes for the first 10 minutes, then at 15, 30, and 60 minutes after drug administration. Cardiac output was determined at 0, 2, 6, 10, 15, 30, and 60 minutes, and blood samples were collected at 0, 2, 10, and 30 minutes. Time to endotracheal extubation, head lift, and ability to sit sternally and walk unaided were recorded.
RESULTS
3 of 6 dogs in each group were apneic after drug administration. Reflexes were decreased similarly for both anesthetic agents, but were not completely lost. Time to sternal position and walking unaided were significantly shorter in response to propofol.
CONCLUSION
Anesthesia was rapid; however, respiratory depression and apnea were major adverse effects associated with propofol and thiopental. Propofol has the advantage of inducing rapid, coordinated anesthesia recovery.