Twenty-five years of K-Cl cotransport: from stimulation by a thiol reaction to cloning of the full-length KCCs.
Twenty-five years of K-Cl cotransport: from stimulation by a thiol reaction to cloning of the full-length KCCs.
复制标题
K-Cl 共转运二十五年：从硫醇反应刺激到全长 KCC 克隆。
DOI：
10.1007/0-387-23752-6_2
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发表时间：
2004
影响因子：
--
通讯作者：
Adragna,NormaC
中科院分区：
文献类型：
--
作者：
Lauf,PeterK;Adragna,NormaC
本章结合了对一种化学干预的研究的回顾，在过去15年的时间里，这种化学干预发生在对钾-氯共转运体(KCC)机制的分子鉴定之前，以及新的数据揭示了一种成功地用于解开这种转运体的动力学、热力学和调节特性的方法的局限性。我们实验室最近对钾-氯共转运、功能、病理和分子性质的综述1以及几篇优秀的早期综述2-5应该参考以了解更多细节。
This chapter combines a review of research on a chemical intervention that, over a period of 15 years, preceded the molecular identification of the mechanism of K-Cl cotransport (potassium chloride cotransporter, KCC) and new data that reveals the caveats of an approach successfully used to unravel kinetic, thermodynamic and regulatory properties of this transporter. A recent comprehensive review from our laboratory on K-Cl cotransport, function, pathology and molecular properties1 as well as several excellent earlier reviews2-5 should be consulted for further details.