FUNCTIONAL-ANATOMY OF LYMPH-NODES .2. PERIPHERAL LYMPH-BORN MONONUCLEAR-CELLS
FUNCTIONAL-ANATOMY OF LYMPH-NODES .2. PERIPHERAL LYMPH-BORN MONONUCLEAR-CELLS
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DOI：
10.1002/ar.1091900103
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发表时间：
1978-01-01
影响因子：
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通讯作者：
GRIFFITHS, S
中科院分区：
文献类型：
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作者：
KELLY, RH;BALFOUR, BM;GRIFFITHS, S
在兔子体内，许多表面膜有皱褶的大单核细胞从腿部皮肤和浅层组织通过淋巴管到达腘淋巴结：它们占传入淋巴中总细胞群的40-50%。当在体外测试时，这些细胞中约10%是活跃的吞噬细胞，约3%含有朗格汉斯颗粒。同位素标记后，大多数淋巴细胞的单核细胞可以检测到区域节点内至少24小时，大多数位于副皮质和少数在滤泡间皮质。这些细胞，包括那些含有朗格汉斯颗粒，可能属于单核吞噬细胞系统。这些淋巴细胞的可能功能进行了讨论，特别是参考抗原运输。
In the rabbit a number of large mononuclear cells with ruffled surface membranes travel from the skin and superficial tissues of the leg, via the lymphatics, to the popliteal lymph node: they constitute 40-50% of the total cell population in the afferent lymph. About 10% of these cells are actively phagocytic when tested in vitro and about 3% contained Langerhans granules. After isotopic labeling, the majority of lymph-borne mononuclear cells can be detected within the regional node for at least 24 h, with most located in the paracortex and a few in the interfollicular cortex. These cells, including those containing Langerhans granules, probably belong to the mononuclear phagocyte system. Possible functions of these lymph-borne cells are discussed with particular reference to antigen transport.