Mechanisms of leukocyte transendothelial migration.
Mechanisms of leukocyte transendothelial migration.
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白细胞跨内皮迁移的机制。
DOI：
10.1146/annurev-pathol-011110-130224
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Muller WA
中科院分区：
文献类型：
--
作者：
Muller WA
除非白细胞跨血管进行静脉，否则天生的免疫系统都会“反应”。来自顶端处置的细胞间粘附分子1和血管细胞粘附分子1，粘附连接的破坏或松动，以及针对血小板/内皮细胞粘合分子的靶向回收，并从最近的横向迁移中迁移。整合了各种已知机制的假设提出了传输的。
Neither the innate nor adaptive immune system “responds” unless leukocytes cross blood vessels. This process occurs through diapedesis, in which the leukocyte moves in an ameboid fashion through tightly apposed endothelial borders and, in some cases, through the endothelial cell itself. This review focuses on the active role of the endothelial cell in diapedesis. Several mechanisms play a critical role in transendothelial migration, including signals derived from clustering of apically disposed intercellular adhesion molecule 1 and vascular cell adhesion molecule 1, disruption or loosening of adherens junctions, and targeted recycling of platelet/endothelial cell adhesion molecule and other molecules from the recently described lateral border recycling compartment. Surprisingly, many of the same molecules and mechanisms that regulate paracellular migration also control transcellular migration. A hypothesis that integrates the various known mechanisms of transmigration is proposed.
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VCAM-1和ICAM-1与粘附白细胞的新型内皮对接结构中的动态相互作用。
DOI：
10.1083/jcb.200112126
发表时间：
2002-06-24
期刊：
The Journal of cell biology
影响因子：
--
作者：
Barreiro O;Yanez-Mo M;Serrador JM;Montoya MC;Vicente-Manzanares M;Tejedor R;Furthmayr H;Sanchez-Madrid F
通讯作者：
Sanchez-Madrid F
影响因子：
4.4
作者：
Carman, CV;Jun, CD;Springer, TA
通讯作者：
Springer, TA
DOI：
10.1152/ajpheart.1997.273.2.h981
发表时间：
1997-08-01
影响因子：
4.8
作者：
Hixenbaugh, EA;Goeckeler, ZM;Huang, AJ
通讯作者：
Huang, AJ
影响因子：
20.3
作者：
Gerard, Audrey;van der Kammen, Rob A.;Collard, John G.
通讯作者：
Collard, John G.
影响因子：
--
作者：
Dufour EM;Deroche A;Bae Y;Muller WA
通讯作者：
Muller WA