Selection for recombination in a polygenic model--the mechanism.
Selection for recombination in a polygenic model--the mechanism.
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多基因模型中重组的选择——机制。
DOI：
10.1017/s0016672300023958
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
J. Maynard Smith
中科院分区：
文献类型：
--
作者：
J. Maynard Smith
一个多基因模型已被模拟，以揭示的过程中，选择在一个无限的人口可以导致等位基因的频率增加，导致更高的重组率（CH等位基因）。定向选择产生排斥连锁不平衡（+ − + −），这种不平衡在CH配子（携带CH等位基因的配子）中不那么强烈。因此，CH配子贡献更大的表型变异性，因此对定向选择的反应更大：也就是说，它们积累了更多选择性偏好的等位基因。然后，CH等位基因通过搭便车增加频率。相反，标准化选择或选择方向的频繁变化有利于等位基因的低重组率。
A polygenic model has been simulated in order to reveal the process whereby selection in an infinite population can lead to an increase in the frequency of alleles causing higher rates of recombination ( CH alleles). Directional selection generates repulsion linkage disequilibrium (+ − + −), which is less strong in CH gametes (gametes carrying CH alleles). In consequence, CH gametes contribute greater phenotypic variability, and therefore respond more to directional selection: that is, they accumulate more selectively favoured alleles. CH alleles then increase in frequency by hitch-hiking. In contrast, normalizing selection, or frequent changes in the direction of selection, favour alleles for a low recombination rate.