Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass.
Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass.
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DOI：
10.3892/etm.2013.1026
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发表时间：
2013-05
影响因子：
2.7
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Zhang Z;Wu Y;Zhao Y;Xiao X;Liu J;Zhou X
高迁移率族蛋白1(HMGB1)由活化的免疫细胞和坏死细胞释放，具有类似于促炎细胞因子的特性。体外循环(CPB)引起全身炎症反应，主动脉阻断引起心肌缺血。本研究观察体外循环期间血HMGB1和肿瘤坏死因子-α水平的动态变化，并分析其临床意义。本研究纳入78例美国麻醉医师协会(ASA)II~IV级体外循环下择期瓣膜置换术患者。分别于麻醉后、术前(T1)、主动脉阻断前(T2)、体外循环后(T3)、术后第1天(T4)、术后第2天(T5)、术后第3天(T6)采血、尿标本测定血清HMGB1、肿瘤坏死因子α、丙氨酸氨基转移酶(ALT)、肌酐(Cr)、尿素氮(BUN)、N-乙酰-β-D-氨基葡萄糖苷酶(NAG)、β-2-微球蛋白(β-2-MG)。结果显示：(1)血清HMGB1水平在T1时升高，在T3时达到高峰，T4时降至较低水平；(2)血清肿瘤坏死因子-α水平在T1时较低，与HMGB1相似，随后下降，至T5时降至最低点；HMGB1水平与血清肿瘤坏死因子-α和血清ALT呈正相关。综上所述，HMGB1水平可作为炎症指标，并可能成为CPB期间控制炎症的新靶点。最佳治疗时间为T3(体外循环后)。
High mobility group box 1 (HMGB1), which is released by activated immune cells and necrotic cells, has properties similar to those of pro-inflammatory cytokines. Cardiopulmonary bypass (CPB) induces systemic inflammation and aortic cross-clamping induces myocardial ischemia. This study was conducted to observe the dynamic changes of HMGB1 and tumor necrosis factor (TNF)-α levels during CPB and to analyze their clinical significance. A total of 78 cases of American Society of Anesthesiologists (ASA) grade II–IV undergoing elective valve replacement under CPB were included in this study. Blood and urine samples were collected after anesthesia prior to surgery (T1), before aortic cross-clamping (T2), after CPB (T3) and on the first day after surgery (T4), as well as the second (T5) and third (T6) day after surgery for determination of the levels of HMGB1, TNF-α, alanine aminotransferase (ALT), creatinine (Cr), blood urea nitrogen (BUN), N-acetyl-β-D-glucosamidase (NAG) and β2-microglobulin (β2-MG). Results revealed that: i) the serum levels of HMGB1 elevated as early as T1, increased until reaching a peak at T3, then decreased to a lower level at T4; ii) the serum level of TNF-α was low at T1, gradually increased in a similar manner to HMGB1, then decreased following CPB and reached the lowest point at T5; and iii) the levels of HMGB1 were positively correlated with serum TNF-α and serum ALT at T3. In conclusion, HMGB1 levels may be used as an indicator of inflammation and may be a novel target for controlling inflammation during CPB. The optimal treatment time is T3 (after CPB).
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影响因子：
30.8
作者：
Calogero, S;Grassi, F;Bianchi, ME
通讯作者：
Bianchi, ME
DOI：
10.1016/s0022-5223(19)33769-9
发表时间：
1993-06-01
影响因子：
6
作者：
DAVIES, SW;DUFFY, JP;WALESBY, RK
通讯作者：
WALESBY, RK
DOI：
10.1152/ajprenal.1995.268.1.f1
发表时间：
1995-01-01
期刊：
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY
影响因子：
--
作者：
BRADY, HR;LAMAS, S;MARSDEN, PA
通讯作者：
MARSDEN, PA
影响因子：
4.3
作者：
MARIN, ML;VEITH, FJ;PARODI, JC
通讯作者：
PARODI, JC
DOI：
10.1152/ajplung.00470.2001
发表时间：
2002-08-01
影响因子：
4.9
作者：
Miakotina, OL;Snyder, JM
通讯作者：
Snyder, JM