Anthracycline-induced phospholipase A2 inhibition.
Anthracycline-induced phospholipase A2 inhibition.
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蒽环类药物诱导的磷脂酶 A2 抑制。
DOI：
10.1007/s12012-007-0012-6
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发表时间：
2007
影响因子：
3.2
通讯作者：
Sarvazyan,Narine
中科院分区：
文献类型：
--
作者：
Swift,Luther;McHowat,Jane;Sarvazyan,Narine
这篇文章的目的是综述我们的发现，膜相关的钙非依赖性磷脂酶A2显著抑制低浓度的临床相关的蒽环类药物。我们的研究表明，由于该酶在膜稳态中的重要作用，它的抑制可能是导致蒽环类药物引起的心功能障碍的早期罪魁祸首之一。这一新现象的临床重要性和潜在的药用价值有待进一步研究。
The purpose of this essay is to overview our findings that membrane-associated calcium-independent phospholipase A2is markedly inhibited by low, clinically relevant concentrations of anthracyclines. Our studies suggest that due to the essential role of this enzyme in membrane homeostasis, its inhibition can be one of the early culprits leading to anthracycline-induced cardiac dysfunction. The clinical importance and potential pharmaceutical use of this new phenomenon await further studies.