THE CLINICALLY TESTED N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST MEMANTINE BLOCKS AND REVERSES THERMAL HYPERALGESIA IN A RAT MODEL OF PAINFUL MONONEUROPATHY
THE CLINICALLY TESTED N-METHYL-D-ASPARTATE RECEPTOR ANTAGONIST MEMANTINE BLOCKS AND REVERSES THERMAL HYPERALGESIA IN A RAT MODEL OF PAINFUL MONONEUROPATHY
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DOI：
10.1016/0304-3940(95)11326-r
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发表时间：
1995-02-24
影响因子：
2.5
通讯作者：
STRASSMAN, AM
中科院分区：
文献类型：
--
作者：
EISENBERG, E;LACROSS, S;STRASSMAN, AM
本研究测试了美金刚（1-氨基-3，5-二甲基-amandate）（一种临床测试的N-甲基-D-天冬氨酸（NMDA）拮抗剂）对疼痛性单神经病大鼠模型中的热痛觉过敏的预防和治疗功效。通过腹膜内植入渗透微泵预防性给予美金刚胺（3.0 mg/kg）7天，可显著降低坐骨神经慢性缩窄性损伤（CCI）诱导的持续性痛觉过敏长达14天。在损伤后第7天和第14天给予美金刚胺（10 mg/kg）的治疗性腹膜内注射在1小时的短时间内完全逆转现有的痛觉过敏。这些结果提供了美金刚胺对疼痛性单神经病模型中的热痛觉过敏产生长期预防和短期治疗作用的证据。
This study tested the prophylactic and therapeutic efficacy of memantine (1-amino-3,5-dimethyl-amandate), a clinically tested N-methyl-D-aspartate (NMDA) antagonist on thermal hyperalgesia in a rat model of painful mononeuropathy. Persistent hyperalgesia induced by chronic constrictive injury (CCI) to the sciatic nerve was significantly reduced for up to 14 days by prophylactic administration of memantine (3.0 mg/kg) via i.p implanted osmotic micropumps for a period of 7 days. Therapeutic i.p injections of memantine (10 mg/kg) given on post-injury days 7 and 14 completely reversed existing hyperalgesia for a short period of 1 h. These results provide evidence that memantine produces long-term prophylactic and short-term therapeutic effects on thermal hyperalgesia in a model of painful mononeuropathy.