Rate variation in the evolution of non-coding DNA associated with social evolution in bees
Rate variation in the evolution of non-coding DNA associated with social evolution in bees
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DOI：
10.1098/rstb.2018.0247
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发表时间：
2019-06
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影响因子：
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通讯作者：
B. E. Rubin;Beryl M. Jones;B. Hunt;Sarah D. Kocher
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文献类型：
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作者：
B. E. Rubin;Beryl M. Jones;B. Hunt;Sarah D. Kocher
优势性的进化起源代表了从个体到种姓为基础的群体繁衍的复杂性的增加。这些行为转变被认为是与调控基因何时何地表达的能力增强同步进行的。蜜蜂趋同地进化了五次共生社会，为检验这一假说提供了一个框架。为了检验假定的基因调控元件和社会进化之间的潜在联系，我们比较了11个不同蜜蜂物种中可比对的非编码序列，包括三个独立的生殖分工起源和两个社会复杂性的阐述。我们发现，一些非编码序列的进化速度与蜜蜂的关键社会转变相关。有趣的是，虽然我们几乎没有发现与社会行为的独立起源相关的收敛速率变化的证据，但一些分子途径显示出收敛速率变化，并与随后对社会组织的阐述相结合。我们还提出了证据，表明许多新的非编码区可能在角蜂的社会性起源的同时被招募；这些基因座可能代表与这一群体内的劳动分工相关的基因调控元件。因此，我们的发现与基因调控创新与共生进化相关的假设是一致的，并说明了对编码和非编码序列的彻底检查如何能够提供对行为进化潜在的分子机制的更完整的理解。本文是主题问题《基因组时代的融合进化：新的见解和方向》的一部分。
The evolutionary origins of eusociality represent increases in complexity from individual to caste-based, group reproduction. These behavioural transitions have been hypothesized to go hand in hand with an increased ability to regulate when and where genes are expressed. Bees have convergently evolved eusociality up to five times, providing a framework to test this hypothesis. To examine potential links between putative gene regulatory elements and social evolution, we compare alignable, non-coding sequences in 11 diverse bee species, encompassing three independent origins of reproductive division of labour and two elaborations of eusocial complexity. We find that rates of evolution in a number of non-coding sequences correlate with key social transitions in bees. Interestingly, while we find little evidence for convergent rate changes associated with independent origins of social behaviour, a number of molecular pathways exhibit convergent rate changes in conjunction with subsequent elaborations of social organization. We also present evidence that many novel non-coding regions may have been recruited alongside the origin of sociality in corbiculate bees; these loci could represent gene regulatory elements associated with division of labour within this group. Thus, our findings are consistent with the hypothesis that gene regulatory innovations are associated with the evolution of eusociality and illustrate how a thorough examination of both coding and non-coding sequence can provide a more complete understanding of the molecular mechanisms underlying behavioural evolution. This article is part of the theme issue ‘Convergent evolution in the genomics era: new insights and directions’.