Reprogram to pluripotency: a new logic and a chemical cocktail.
Reprogram to pluripotency: a new logic and a chemical cocktail.
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DOI：
10.1093/nsr/nwt007
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发表时间：
2014-03
影响因子：
20.6
通讯作者：
Ming GL
中科院分区：
文献类型：
--
作者：
Song H;Ming GL
动物和人类的体细胞可以通过多能因子重新编程为多能干细胞。邓洪奎及其同事发现，外源谱系指定子也可以通过平衡相互竞争的分化力量来诱导多能性。在一项相关的研究中，他们首次实现了仅使用一种化学鸡尾酒就能恢复成年体细胞的多能性。
Somatic cells from animals and humans can be reprogrammed into pluripotent stem cells by pluripotency factors. Hongkui Deng and colleagues discovered that pluripotency can also be induced with exogenous lineage specifiers via balancing competing differentiation forces. In a related study they achieved, for the first time, restoration of pluripotency in adult somatic cells using a chemical cocktail alone.