Association between family history of affective disorder and the depressive syndrome of Alzheimer's disease.
Association between family history of affective disorder and the depressive syndrome of Alzheimer's disease.
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情感障碍家族史与阿尔茨海默病抑郁综合征之间的关联。
DOI：
10.1176/ajp.147.4.452
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Folstein,MF
中科院分区：
文献类型：
--
作者：
Pearlson,GD;Ross,CA;Lohr,WD;Rovner,BW;Chase,GA;Folstein,MF
方法 我们从 400 名连续转诊的患者中选择了索引和比较对象，这些患者于 1979 年 1 月至 1984 年 1 月期间在约翰·霍普金斯大学精神病学部痴呆研究诊所接受评估，了解晚年开始的认知衰退症状。我们检查了所有这些人的图表，以确定他们中的哪些人符合 DSM-III 原发性退行性痴呆的诊断标准，以及根据国家神经和交流障碍和中风研究所 (NINCDS) 以及阿尔茨海默病和相关疾病协会 (ADRDA) (ADRDA) 的标准诊断可能的阿尔茨海默病 (15)。在评估时，每位患者均由主治精神科医生进行检查，并接受身体和神经系统检查以及相关的血液检测；从一名或多名亲属处获取了详细的病史。患有其他原因的痴呆症、CT 扫描有局灶性发现或 Hachinski 评分 (16) 高于 4 的患者被排除在研究之外。在初次就诊时记录每位患者的简易精神状态检查得分 (17)。我们确定了 41 名患者，他们在初步评估时或随后的随访中被主治精神科医生诊断为患有重度抑郁发作。这些指数患者经我们两人（GDP 和 CAR）独立判断，均符合 DSM-III 检查表规定的重度抑郁发作标准，并且既往没有情感障碍个人史。负面的个人历史最初是通过重新确定的
METHODWe selected index and comparison subjects from 400 consecutively referred patients who were evaluated at the Johns Hopkins Department of Psychiatry’s Dementia Research Clinic between January 1979 and January 1984 for symptoms of cognitive decline beginfling in late life. We examined the charts of all such individuals to determine which of them had met critena for a DSM-III diagnosis of primary degenerative dementia and a diagnosis of probable Alzheimer’s disease made according to the criteria of the National Institute of Neurological and Communicative Disordens and Stroke (NINCDS) and the Alzheimer’s Disease and Related Disorders Association(ADRDA)(15). At the time of assessment each patient was cxamined by an attending psychiatrist and underwent physical and neurological examinations and relevant blood testing; a detailed history was taken from one or more relatives. Patients with other causes of dementia, CT scans with focal findings, or Hachinski scores (16) higher than 4 were excluded from the study. Each patient’s score on the Mini-Mental State Examination (17) was recorded at the time of the initial visit. We identified 41 patients who were diagnosed by the attending psychiatrist at the time of initial evaluation or at subsequent follow-up as suffering from a major depressive episode. These index patients were mdcpendently judged by two of us (GDP and CAR) both to have met the criteria for a major depressive episode according to a DSM-III checklist and to have no prior personal history of affective disorder. Nega-tive personal history was initially determined by re-