DBTSS, DataBase of Transcriptional Start Sites: progress report 2004
DBTSS, DataBase of Transcriptional Start Sites: progress report 2004
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DOI：
10.1093/nar/gkh076
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发表时间：
2004-01-01
影响因子：
14.9
通讯作者：
Nakai, K
中科院分区：
文献类型：
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作者：
Suzuki, Y;Yamashita, R;Nakai, K
DBTSS（dbtss.hgc.jp）最初是基于实验确定的人类基因TSS的集合构建的。自2002年首次发布以来，它已多次更新。首先，存储的数据量显著增加：例如，与RefSeq mRNA集和基因组序列匹配的克隆数量从111382增加到190964，现在覆盖了11234个基因。第二，dbSNP中SNP的位置显示在所含人类基因的上游区域。第三，DBTSS现在涵盖其他物种，如小鼠和人类疟疾寄生虫。它将成为一个中央数据库，包含更多使用寡帽和相关方法的物种的数据。最后，该数据库现在用于比较启动子分析：在当前版本中，提供了来自人类和小鼠的潜在正向启动子的比较视图，并提供了搜索潜在转录因子结合位点的额外功能，这些位点在物种之间是保守的或发散的。
DBTSS (http://dbtss.hgc.jp) was originally constructed based on a collection of experimentally determined TSSs of human genes. Since its first release in 2002, it has been updated several times. First, the amount of stored data has increased significantly: e.g. the number of clones that match both the RefSeq mRNA set and the genome sequence has increased from 111382 to 190 964, now covering 11234 genes. Second, the positions of SNPs in dbSNP were displayed on the upstream regions of contained human genes. Third, DBTSS now covers other species such as mouse and the human malaria parasite. It will become a central database containing data for many more species with oligocapping and related methods. Lastly, the database now serves for comparative promoter analyses: in the current version, comparative views of potentially orthologous promoters from human and mouse are presented with an additional function of searching potential transcription-factor binding sites, which are either conserved or diverged between species.