Cryotherapy and other newer techniques.
Cryotherapy and other newer techniques.
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DOI：
10.1016/s1052-5157(03)00044-8
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发表时间：
2003-07-01
影响因子：
--
通讯作者：
Johnston, Mark H
中科院分区：
文献类型：
--
作者：
Johnston, Mark H
随着新技术的发展，Barrett粘膜消融的潜在方式正在增加。最新的三种是高压和低压喷雾冷冻疗法和超声上皮消融术。关于低压喷雾冷冻疗法的数据特别有希望。它的消融深度约为2 mm，技术上易于执行，并且相对于其他热技术，涉及独特的细胞损伤机制，可能被证明非常适合治疗GI肿瘤和癌前病变，如巴雷特食管。国家海军医疗中心正在进行巴雷特冷冻消融试验。
Potential modalities for the ablation of Barrett's mucosa are increasing with new technologies. Three of the newest are high- and low-pressure spray cryotherapy and ultrasonic epithelial ablation. Data regarding low-pressure spray cryotherapy are particularly promising. It has a depth of ablation approximating 2 mm, is technically easy to perform, and involves unique cellular mechanisms of injury relative to other thermal techniques that may prove ideally suited for the treatment of GI neoplasms and premalignant lesions such as Barrett's esophagus. A Barrett's ablation trial with cryotherapy is ongoing at the National Naval Medical Center.