Prevalence and Etiology of Dementia in a Japanese Community
Prevalence and Etiology of Dementia in a Japanese Community
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DOI：
10.1161/01.str.23.6.798
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发表时间：
1992-06
期刊：
影响因子：
8.3
通讯作者：
K. Ueda;H. Kawano;Y. Hasuo;M. Fujishima
中科院分区：
文献类型：
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作者：
K. Ueda;H. Kawano;Y. Hasuo;M. Fujishima
背景和目的：我们试图确定类型特异性痴呆症的患病率及其危险因素，在老年人从日本社区的久山。方法采用临床资料、神经系统检查和痴呆量表等方法，对887名（男353名，女534名）65岁以上的久山县居民（筛查率为94.6%）进行痴呆患病率调查。我们还研究了50的59确定有痴呆症的计算机断层扫描或尸检在随后的54个月期间的脑形态。对27例血管性痴呆患者和789例非痴呆对照者的痴呆相关因素进行回顾性比较。结果久山县65岁以上居民的痴呆症患病率为6.7%，男女比例为1：2。在对50例痴呆患者进行脑形态学检查时，血管性痴呆的发生率为56%，是Alzheimer型老年痴呆的2.2倍。年龄、高血压、心电图异常和高红细胞压积与血管性痴呆的发生显著相关（p<0.05）。结论鸠山县居民痴呆的患病率与以前报道的比较一致，但血管性痴呆更占优势。血管性痴呆的危险因素与腔隙性脑梗死相似。控制高血压可能是减少日本人口痴呆症的关键。
Background and Purpose We sought to determine the type-specific prevalence of dementia and its risk factors in elderly persons from the Japanese community of Hisayama. Methods We studied the prevalence of dementia in 887 Hisayama residents (353 men and 534 women) aged 65 years or older (screening rate, 94.6%) using various items of clinical information, neurological examination, and dementia scales. We also studied brain morphology in 50 of 59 determined to have dementia by computed tomography or autopsy during the subsequent 54-month period. Factors relevant dementia were compared between 27 patients with vascular dementia and 789 control subjects without dementia in a retrospective fashion. Results The prevalence rate of dementia among Hisayama residents aged 65 or older was estimated at 6.7%, with a females to males ratio of 1:2. Among 50 cases of dementia in which brain morphology was examined, the frequency of vascular dementia was 56%; this rate was 2.2 times higher than that for senile dementia of the Alzheimer type. Aging, hypertension, electrocardiographic abnormalities, and high hematocrit were significantly (p<0.05) and independently associated with the occurrence of vascular dementia. Conclusions Prevalence of dementia among the Hisayama residents was relatively identical to that previously reported, but vascular dementia was more predominant Risk factors for vascular dementia were similar to those for lacunar infarcts. Control of hypertension may be a key to reducing dementia among the Japanese population.