The genetic and cellular basis of regulation of the immune response to tumor antigens.
The genetic and cellular basis of regulation of the immune response to tumor antigens.
复制标题
肿瘤抗原免疫反应调节的遗传和细胞基础。
DOI：
10.1007/978-1-4684-3701-0_2
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
M. I. Greene
中科院分区：
文献类型：
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作者：
M. I. Greene
在本章中，我讨论了肿瘤抗原免疫反应调节的细胞和遗传基础。我有意省略了对 ADCC、NK 和 B 细胞等效应器的讨论，因为我自己对此类效应器的经验主要涉及与小肿瘤接种物相关的早期事件（Greenberg 和 Greene，1976）。在该模型中，天然抗体和巨噬细胞参与的 NK 和 ADCC 机制很重要，而 T 细胞则不然。在我在此进行的研究中，已经评估了更先进的肿瘤模型。我希望从本章中可以清楚地看出，了解免疫细胞或 Ts 激活途径将为未来应用免疫治疗技术奠定基础。
In this chapter I have dealt with the cellular and genetic basis of regulation of the immune response to tumor antigen. I have knowingly omitted discussion of effectors such as ADCC, NK, and B cells, since my own experience with such effectors relates primarily to early events associated with small-tumor inocula (Greenberg and Greene, 1976). In that model, NK and ADCC mechanisms, in which natural antibody and macrophages participate, are of importance and T cells are not. In the studies I have dealt with herein, more advanced tumor models have been evaluated. It is clear, I hope, from this chapter that understanding the pathways to immune-cell or Ts activation will provide the basis for applied immunotherapy techniques in the future.
DOI：
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发表时间：
1980
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
Burakoff,SJ;Riccio,J;Billings,P;Benacerraf,B;Dorf,ME
通讯作者：
Dorf,ME