Lymphocyte abnormality associated with HLA-B8 in healthy young adults
Lymphocyte abnormality associated with HLA-B8 in healthy young adults
复制标题
健康年轻人中与 HLA-B8 相关的淋巴细胞异常
DOI：
--
复制
发表时间：
1982
影响因子：
15.3
通讯作者：
J. Michalski
中科院分区：
文献类型：
--
作者：
C. McCombs;J. Michalski
我们曾报道干燥综合征中淋巴细胞功能异常几乎只发生在HLA-B8患者中。我们现在报告，大多数临床正常的个人与这种抗原有类似的损害细胞免疫。这一发现表明，干燥综合征的淋巴细胞异常不是继发于疾病过程或药物，可能有主要的病因学意义。淋巴细胞异常表现为对植物血凝素（PHA）和伴刀豆球蛋白A（Con A）的次最佳刺激浓度的增殖反应降低。相反，对PHA和Con A的最佳刺激浓度的反应不受影响。受损的丝裂原反应性似乎是T淋巴细胞固有的，正如它可以在纯化的T细胞制剂中证明的那样。
We have reported that abnormal lymphocyte function in Sjogren's syndrome occurs almost exclusively in patients with HLA-B8. We now report that most clinically normal individuals with this antigen have a similar impairment of cellular immunity. This finding suggests that the lymphocyte abnormality in Sjogren's syndrome is not secondary to the disease process or medication and might have primary etiological significance. The lymphocyte abnormality is expressed as a decreased proliferative response to suboptimally stimulating concentrations of phytohemagglutinin (PHA) and concanavalin A (Con A). In contrast, the response to optimally stimulating concentrations of PHA and Con A is unaffected. The imparied mitogen responsiveness appears to be intrinsic to the T lymphocytes, as it can be demonstrated in purified T cell preparations.