Numerical investigation of two-dimensional light scattering patterns of cervical cell nuclei to map dysplastic changes at different epithelial depths
Numerical investigation of two-dimensional light scattering patterns of cervical cell nuclei to map dysplastic changes at different epithelial depths
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DOI：
10.1364/boe.5.000485
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发表时间：
2014-02-01
影响因子：
3.4
通讯作者：
Guillaud, Martial
中科院分区：
文献类型：
--
作者：
Arifler, Dizem;MacAulay, Calum;Guillaud, Martial
我们使用一套广泛的定量组织病理学数据来构建不同上皮深度的正常和发育不良宫颈细胞核的真实三维模型。然后，我们采用时域有限差分法数值模拟这些代表性的模型作为一个函数的极散射角和方位角的光散射响应。结果表明，从二维散射模式计算的强度和形状度量可用于区分不同的诊断类别。我们的数值研究还表明，不同的上皮层和角度范围需要单独考虑，以充分利用二维光散射测量的诊断潜力。(C)2014年美国光学学会
We use an extensive set of quantitative histopathology data to construct realistic three-dimensional models of normal and dysplastic cervical cell nuclei at different epithelial depths. We then employ the finite-difference time-domain method to numerically simulate the light scattering response of these representative models as a function of the polar and azimuthal scattering angles. The results indicate that intensity and shape metrics computed from two-dimensional scattering patterns can be used to distinguish between different diagnostic categories. Our numerical study also suggests that different epithelial layers and angular ranges need to be considered separately to fully exploit the diagnostic potential of two-dimensional light scattering measurements. (C) 2014 Optical Society of America