Tissue-level signaling and control of uterine contractility: the action potential-calcium wave hypothesis.
Tissue-level signaling and control of uterine contractility: the action potential-calcium wave hypothesis.
复制标题
组织水平信号传导和子宫收缩力的控制：动作电位-钙波假说。
DOI：
10.1016/s1071-5576(00)00041-1
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Young,RC
中科院分区：
文献类型：
--
作者：
Young,RC
本文介绍了子宫收缩的动作电位-钙波假说。两种已知的细胞间组织水平信号传递机制被合并为器官水平信号传递的单一假说。这一假说提供了一个将细胞生理学与器官功能联系起来的框架。组织水平信号传递的两种机制是动作电位传播和细胞间钙波。大量的文献都是关于平滑肌和肌层的电兴奋性的。尽管有这些知识，但似乎不可能使熟悉的子宫收缩曲线与已知的细胞生理学参数相一致，除非假设细胞间通讯的第二种机制。细胞内钙波符合第二种机制所需的要求：速度慢，能够提高细胞内游离钙，以及能够发出超过数百微米的信号。动作电位-钙波假说的前提是动作电位在子宫内迅速传播，引发细胞间钙波。当细胞间钙波通过肌束缓慢传播时，心肌细胞被招募来参与收缩。本文回顾和总结了有关人子宫肌层钙波的文献，并提出了支持这些机制组合的证据。这一假说的延伸表明，人类分娩子宫的功能单位是平滑肌束，子宫收缩的频率和强度是分开的，但又是联系在一起的分娩的生理特征。
This article describes the action potential—calcium wave hypothesis of uterine contractility. Two known mechanisms of intercellular tissue-level signaling are merged into a single hypothesis of organ-level signaling. This hypothesis provides a framework with which to link cellular physiology with organ function. The two mechanisms of tissue-level signaling considered are action potential propagation and intercellular calcium waves. A great body of literature exists regarding the electrical excitability of smooth muscle and myometrium. Despite this knowledge, it does not seem possible to reconcile the familiar uterine contraction profile with known paraneters of cellular physiology unless a second mechanism of intercellular communication is postulated. Intercellular calcium waves fit the requirements needed for the second mechanism: slow speed, ability to raise interacellular free calcium, and ability to signal over hundreds of micrometers. The premise of the action potential—calcium wave hypothesis is that action potentials propagate rapidly throughout the uterus, initiating intercellular calcium waves. As the intercellular calcium waves propagate slowly through the bundles, myocytes are recruited to participate in the contraction. This article reviews and summarizes the literature on calcium waves in human myometrium and presents evidence to support the combination of these mechanisms. Extension of the hypothesis suggests that the functional unit of the laboring human uterus is the smooth-muscle bundle, and that the frequency and strength of uterine contractions are separate but linked physiologic characteristic of labor.