Effects of glucose-dependent insulinotropic peptide on behavior
Effects of glucose-dependent insulinotropic peptide on behavior
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DOI：
10.1016/j.peptides.2006.05.011
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发表时间：
2006-11-01
期刊：
影响因子：
3
通讯作者：
Isales, Carlos M.
中科院分区：
文献类型：
--
作者：
Ding, Ke-Hong;Zhong, Qing;Isales, Carlos M.
葡萄糖依赖型促胰岛素肽(GIP)是一种胰岛素样激素，在营养摄入后迅速升高。GIP受体在脑中广泛表达，包括脑干、端脑、间脑、嗅球、垂体和小脑。直到最近，人们还不清楚这种受体的内源性配体是什么，因为在大脑中还没有发现GIP表达。GIP的合成现在已经在海马齿状回被记录下来。为了确定GIP对行为的影响，我们使用了一种小鼠模型，即GIP过表达的转基因小鼠(GIPTG)。具体而言，研究对象包括与焦虑相关的行为、探索、记忆和伤害感。与年龄匹配的成年雄性C57BI/6对照组相比，GIP TG小鼠在旷场运动活动测试中表现出更强的探索行为。GIP转基因小鼠在一些运动功能测试中也表现出了提高的表现。这些数据表明，GIP受体在运动活动和探索的调节中发挥作用。据我们所知，这是关于GIP对行为影响的第一份报告。(C)2006 Elsevier Inc.保留所有权利。
Glucose-dependent insulinotropic peptide (GIP) is an incretin hormone that rises rapidly in response to nutrient ingestion. The GIP receptor is widely expressed in the brain including the brain stem, telencephalon, diencephalon, olfactory bulb, pituitary, and cerebellum. Until recently it was not clear what the endogenous ligand for this receptor was because no GIP expression had been demonstrated in the brain. GIP synthesis has now been documented in the dentate gyrus of the hippocampus. To define GIP effects on behavior we utilized a mouse model a GIP-overexpressing transgenic mouse (GIP Tg). Specifically, anxiety-related behavior, exploration, memory, and nociception were examined. Compared to age-matched adult male C57BI/6 controls GIP Tg mice displayed enhanced exploratory behavior in the open-field locomotor activity test. GIP Tg mice also demonstrated increased performance in some of the motor function tests. These data suggest that the GIP receptor plays a role in the regulation of locomotor activity and exploration. To our knowledge, this is the first report of effects of GIP on behavior. (c) 2006 Elsevier Inc. All rights reserved.